Mitotane

small molecule

Identifier: CI-DRUG-00000670
Entity page: /drug/mitotane ↗
Edges: 21

Neighbours: 7 cancers2 genes9 trials1 approvals
Drawn: 19 of 19 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Mitotane approved for …APPROVED_FOR4 of 3
→ approved for	Adrenal Cortical Carcinomasubtype	supports	FDA ORIG	Adrenal Cortical Carcinoma	1	Regulatory	openfda	graph →
→ approved for	Adrenal Cortical Carcinomasubtype	supports	EMA indication text

Mitotane targets …TARGETS2 of 2
→ targets	CYP11A1	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	CYP11B1	—	INHIBITOR	—	1	Curated	chembl	graph →

Mitotane targets …TARGETS2 of 2

→ targets

CYP11A1

—

INHIBITOR

—

Curated

Mitotane investigated for …INVESTIGATED_FOR3 of 3
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Adrenal Cortical Neoplasmsubtype	unknown	4	Adrenal Cortical Neoplasm	1	Curated	chembl	graph →
→ investigated for	Carcinomacancer_family	unknown	3	Carcinoma	1	Curated	chembl	graph →

Mitotane investigated in trials for …INVESTIGATED_IN_TRIALSderived4 of 4
→ investigated in trials for	Adrenal Cortical Carcinomasubtype 7 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adrenal Cortical Carcinoma	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Adrenal Gland Neoplasm 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adrenal Gland Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Adrenal Gland Neoplasm 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Adrenal Gland Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Prostate Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Prostate Neoplasm	1	Observed	clinicaltrials	graph →

Mitotane studied in …STUDIED_INderived9 of 9
→ studied in	NCT03583710Phase 3 · recruiting Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Patients With Stage I-III Adrenocortical Cancer With High Risk of Recurrence · 9 trials list this drug (2 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT05634577Phase 2 · terminated A Phase II Study to Evaluate the Efficacy and Safety of Pembrolizumab in Combination With Mitotane in Patients With Advanced Adrenocortical Carcinoma · 9 trials list this drug (2 active)	—	—	Adrenal Cortical Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06831175Phase 2 · recruiting Phase II Study of PD-1 Inhibitor Combined With Apatinib and Mitotane in the Treatment of Advanced Adrenal Cortical Carcinoma · 9 trials list this drug (2 active)	—	—	Adrenal Gland Neoplasm,Adrenal Cortical Carcinoma,Malignant Adrenal Gland Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT00304070Phase 3 · completed Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical Tumor · 9 trials list this drug (2 active)	—	—	Adrenal Cortical Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05344027completed The Impact of Mitotane Therapy on Serum Free Proteins in Patients With Adrenocortical Carcinoma · 9 trials list this drug (2 active)	—	—	Adrenal Cortical Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00777244Phase 3 · unknown Efficacy of Adjuvant Mitotane Treatment (ADIUVO) · 9 trials list this drug (2 active)	—	—	Adrenal Cortical Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00094497Phase 3 · completed Trial in Locally Advanced and Metastatic Adrenocortical Carcinoma Treatment (FIRM-ACT) · 9 trials list this drug (2 active)	—	—	Adrenal Cortical Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02057237Phase 1 · completed A Safety and Feasibility Study of Mitotane in Prostate Cancer · 9 trials list this drug (2 active)	—	—	Malignant Prostate Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT00778817Phase 2 · terminated IMC-A12 With Mitotane vs Mitotane Alone in Recurrent, Metastatic, or Primary ACC That Cannot Be Removed by Surgery · 9 trials list this drug (2 active)	—	—	Adrenal Cortical Carcinoma	1	Observed	clinicaltrials	graph →

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