Megestrol

small molecule

Identifier: CI-DRUG-00000669
Entity page: /drug/megestrol ↗
Edges: 93

Neighbours: 22 cancers1 genes10 trials13 approvals
Drawn: 46 of 46 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Megestrol approved for …APPROVED_FOR14 of 13
→ approved for	Breast Carcinomasubtype	supports	FDA ORIG	Breast Carcinoma	1	Regulatory	openfda	graph →
→ approved for	Health Canada · CA · 1997Marketed in Canada as MEGESTROL-40 - TAB 40MG (DIN 02223104) under ATC L02AB01 MEGESTROL. Indications are not published in the Drug Product Database — see the Health Canada Product Monograph.

Megestrol targets …TARGETS1 of 1
→ targets	PGR	—	AGONIST	—	1	Curated	chembl	graph →

Megestrol targets …TARGETS1 of 1

→ targets

PGR

—

AGONIST

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Curated

Megestrol investigated for …INVESTIGATED_FOR8 of 8
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Liver Neoplasmsubtype	unknown	3	Liver Neoplasm	1	Curated	chembl	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	3	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Endometrial Neoplasmsubtype	unknown	3	Endometrial Neoplasm	1	Curated	chembl	graph →
→ investigated for	Carcinoma In Situhistology	unknown	2	Carcinoma In Situ	1	Curated	chembl	graph →
→ investigated for	Adrenal Cortical Neoplasmsubtype	unknown	2	Adrenal Cortical Neoplasm	1	Curated	chembl	graph →
→ investigated for	Uterine Neoplasmsubtype	unknown	2	Uterine Neoplasm	1	Curated	chembl	graph →
→ investigated for	Head and Neck Neoplasmcancer_family	unknown	2	Head and Neck Neoplasm	1	Curated	chembl	graph →

Megestrol investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 28show all (up to 200)
→ investigated in trials for	Endometrial Carcinoma 7 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Endometrial Carcinoma	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Endometrial Neoplasm 7 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Endometrial Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Breast Neoplasm 6 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia 4 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Endometrial Neoplasmsubtype 3 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Endometrial Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Solid Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Solid Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Endometrial Endometrioid Adenocarcinoma 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Endometrial Endometrioid Adenocarcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Head and Neck Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Head and Neck Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Uterine Corpus Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Uterine Corpus Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Brain Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Brain Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Breast Neoplasmcancer_family 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Central Nervous System Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Central Nervous System Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Childhood Solid Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Childhood Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Endometrial Adenocarcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Endometrial Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma	1	Observed	clinicaltrials	graph →

Megestrol studied in …STUDIED_INderived10 of 43show all (up to 200)
→ studied in	NCT00420563Phase 2 · completed Metronomic Chemotherapy by Cyclophosphamide Versus Megestrol in Palliative Cancer · 43 trials list this drug (11 active)	—	—	Malignant Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04939090Phase 3 · active not recruiting Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients · 43 trials list this drug (11 active)	—	—	Hematopoietic and Lymphoid Cell Neoplasm,Malignant Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05538897Phase 1/Phase 2 · active not recruiting Testing the Addition of the AKT Inhibitor, Ipatasertib, to Treatment With the Hormonal Agent Megestrol Acetate for Recurrent or Metastatic Endometrial Cancers · 43 trials list this drug (11 active)	—	—	Endometrial Endometrioid Adenocarcinoma,FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma,FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07436793Phase 2 · recruiting Progestins for the Treatment of Endometrial Cancer or Precancers of the Uterus Before Surgery, The Pro-Window Trial · 43 trials list this drug (11 active)	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05247268Phase 2 · recruiting Gonadotropin-releasing Hormone Agonist (GnRHa) Plus Letrozole In Young Women With Early Endometrial Cancer · 43 trials list this drug (11 active)	—	—	Endometrial Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05316467Phase 2/Phase 3 · terminated Weight Management Plus Megestrol Acetate in Early-stage Endometrioid Carcinoma · 43 trials list this drug (11 active)	—	—	Endometrial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03671811Phase 2 · active not recruiting Megestrol Acetate With or Without Pterostilbene in Treating Patients With Endometrial Cancer Undergoing Hysterectomy · 43 trials list this drug (11 active)	—	—	Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia,Endometrial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05255653Phase 2/Phase 3 · recruiting Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features · 43 trials list this drug (11 active)	—	—	Malignant Endometrial Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07319429Phase 2/Phase 3 · recruiting Refining Fertility-sparing Treatment in Endometrial Carcinoma Based on Molecular Classification · 43 trials list this drug (11 active)	—	—	Malignant Endometrial Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04576104Phase 2 · active not recruiting Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer · 43 trials list this drug (11 active)	—	—	Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia,Endometrial Carcinoma	1	Observed	clinicaltrials	graph →

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