Imlunestrant

small molecule

Identifier: CI-DRUG-00000810
Entity page: /drug/imlunestrant ↗
Edges: 22

Neighbours: 8 cancers10 trials
Drawn: 18 of 18 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Imlunestrant approved for …APPROVED_FOR3 of 3
→ approved for	Malignant Breast Neoplasmcancer_family	supports	FDA ORIG	Malignant Breast Neoplasm	1	Regulatory	openfda	graph →
→ approved for	Malignant Breast Neoplasmcancer_family	supports	EMA indication text

Imlunestrant investigated for …INVESTIGATED_FOR2 of 2
→ investigated for	Breast Neoplasmcancer_family	unknown	3	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	2	Neoplasm	1	Curated	chembl	graph →

Imlunestrant investigated for …INVESTIGATED_FOR2 of 2

→ investigated for

Breast Neoplasmcancer_family

unknown

Breast Neoplasm

Curated

Imlunestrant investigated in trials for …INVESTIGATED_IN_TRIALSderived7 of 7
→ investigated in trials for	Breast Neoplasmcancer_family 4 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Breast Neoplasmcancer_family 4 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Endometrial Neoplasm 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Endometrial Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Solid Neoplasm 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Estrogen Receptor-Positive Breast Carcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Estrogen Receptor-Positive Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Invasive Breast Carcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Invasive Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Ovarian Low Grade Serous Adenocarcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Ovarian Low Grade Serous Adenocarcinoma	1	Observed	clinicaltrials	graph →

Imlunestrant studied in …STUDIED_INderived10 of 10
→ studied in	NCT07287098Phase 2 · recruiting A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer · 10 trials list this drug (9 active)	—	—	Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07832227Phase 2 · not yet recruiting Imlunestrant/Abemaciclib/Selinexor in Ovarian and Endometrial · 10 trials list this drug (9 active)	—	—	Ovarian Low Grade Serous Adenocarcinoma,Malignant Endometrial Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05307705Phase 1 · recruiting A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors · 10 trials list this drug (9 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07191717Phase 2 · recruiting Imlunestrant and Abemaciclib for the Treatment of Estrogen Receptor Positive Breast Cancer in Patients With Minimal Residual Disease, MIRI Trial · 10 trials list this drug (9 active)	—	—	Invasive Breast Carcinoma,Estrogen Receptor-Positive Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04975308Phase 3 · active not recruiting A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer · 10 trials list this drug (9 active)	—	—	Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05768139Phase 1/Phase 2 · recruiting First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors · 10 trials list this drug (9 active)	—	—	Adult Solid Neoplasm,Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04188548Phase 1 · active not recruiting A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer · 10 trials list this drug (9 active)	—	—	Malignant Breast Neoplasm,Malignant Endometrial Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05509790Phase 1 · active not recruiting A Study of LY3484356 in Chinese Participants With Advanced Breast Cancer · 10 trials list this drug (9 active)	—	—	Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05514054Phase 3 · active not recruiting A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer · 10 trials list this drug (9 active)	—	—	Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04647487Phase 1 · completed A Study of LY3484356 in Women With Breast Cancer Before Having Surgery · 10 trials list this drug (9 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →

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