FOLFIRI Regimen

Identifier: CI-DRUG-00000238
Entity page: /drug/folfiri-regimen ↗
Edges: 181

Neighbours: 15 cancers2 variants10 trials
Drawn: 27 of 27 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
FOLFIRI Regimen predicts response to …PREDICTS_RESPONSE_TO2 of 2
← predicts response to	PPP1R15A RS557806SNV	sensitivity	B	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
← predicts response to	TOP1 Amplificationamplification	sensitivity	B

FOLFIRI Regimen investigated for …INVESTIGATED_FOR1 of 1
→ investigated for	Malignant Colorectal Neoplasmsubtype 2 source records aggregated	supports	B	Malignant Colorectal Neoplasm	2	Curated	civic	graph →

FOLFIRI Regimen investigated for …INVESTIGATED_FOR1 of 1

→ investigated for

Malignant Colorectal Neoplasmsubtype

2 source records aggregated

supports

Malignant Colorectal Neoplasm

Curated

FOLFIRI Regimen investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 42show all (up to 200)
→ investigated in trials for	Malignant Colorectal Neoplasmsubtype 83 trials (16 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	83	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Neoplasm 17 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Neoplasm	17	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 10 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colon Neoplasm 9 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colon Neoplasm	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 9 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Carcinoma 7 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Carcinoma	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Gastric Neoplasm 5 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Gastric Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Pancreatic Neoplasm 5 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Pancreatic Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Rectal Neoplasm 5 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Rectal Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Digestive System Neoplasm 4 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Digestive System Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Digestive System Neoplasm 3 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Digestive System Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Gastric Neoplasm 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Gastric Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Pancreatic Adenocarcinoma 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Pancreatic Adenocarcinoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Adenocarcinoma 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Adenocarcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinoma 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	2	Observed	clinicaltrials	graph →

FOLFIRI Regimen studied in …STUDIED_INderived10 of 136show all (up to 200)
→ studied in	NCT04793958Phase 3 · active not recruiting Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10) · 136 trials list this drug (29 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07446322Phase 2 · recruiting FOLFIRI and Bevacizumab With or Without Pelareorep for Second-Line Treatment of Metastatic RAS-Mutated, Microsatellite-Stable Colorectal Cancer · 136 trials list this drug (29 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT06663319Phase 1 · recruiting A Study of JNJ-89402638 for Metastatic Colorectal and Gastric Cancers · 136 trials list this drug (29 active)	—	—	Digestive System Neoplasm,Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07221357Phase 2/Phase 3 · recruiting A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer · 136 trials list this drug (29 active)	—	—	Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06445062Phase 1/Phase 2 · recruiting Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors · 136 trials list this drug (29 active)	—	—	Malignant Digestive System Neoplasm,Colorectal Carcinoma,Malignant Colorectal Neoplasm+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT05786924Phase 1/Phase 2 · recruiting Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies · 136 trials list this drug (29 active)	—	—	Solid Neoplasm,Histiocytic and Dendritic Cell Neoplasm,Malignant Lung Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT04485013Phase 1 · active not recruiting TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers · 136 trials list this drug (29 active)	—	—	Malignant Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04929223Phase 1 · recruiting A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC) · 136 trials list this drug (29 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07702032Phase 3 · recruiting Study of Petosemtamab Plus Chemotherapy Versus Cetuximab Plus Chemotherapy in RAS and BRAF Wild-type, Unresectable or Metastatic, Left-sided Colorectal Cancer (LiGeR-CRC1) · 136 trials list this drug (29 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT06252649Phase 3 · recruiting Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation · 136 trials list this drug (29 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →

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