Plasma Cell Leukemia

hematologic malignancy

Identifier: CI-CAN-00001421
Entity page: /cancer/plasma-cell-leukemia ↗
Edges: 103

Neighbours: 24 drugs10 trials
Drawn: 34 of 34 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Plasma Cell Leukemia investigated for …INVESTIGATED_FOR20 of 20show fewer
← investigated for	Pomalidomidesmall_molecule	unknown	2	Plasma Cell Leukemia	1	Curated	chembl	graph →
← investigated for	Panobinostatsmall_molecule	unknown	2

Plasma Cell Leukemia investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 30show all (up to 200)
→ investigated in trials for	Fludarabinesmall molecule 9 trials (2 active) · roll-up of the cancer and its descendants	—	—	Plasma Cell Leukemia	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall_molecule 8 trials (2 active) · roll-up of the cancer and its descendants	—	—	Plasma Cell Leukemia	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Melphalansmall_molecule 8 trials (1 active) · roll-up of the cancer and its descendants	—	—	Plasma Cell Leukemia	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Lenalidomidesmall_molecule 7 trials (4 active) · roll-up of the cancer and its descendants	—	—	Plasma Cell Leukemia	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Bortezomibsmall_molecule 5 trials (1 active) · roll-up of the cancer and its descendants	—	—	Plasma Cell Leukemia	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Dexamethasonesmall_molecule 5 trials (2 active) · roll-up of the cancer and its descendants	—	—	Plasma Cell Leukemia	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Carfilzomibother 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Plasma Cell Leukemia	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Daratumumabmonoclonal_antibody 3 trials (2 active) · roll-up of the cancer and its descendants	—	—	Plasma Cell Leukemia	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Teclistamabmonoclonal antibody 3 trials (3 active) · roll-up of the cancer and its descendants	—	—	Plasma Cell Leukemia	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Carmustinesmall_molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Plasma Cell Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Cytarabinesmall_molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Plasma Cell Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall_molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Plasma Cell Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Filgrastimother 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Plasma Cell Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Isatuximabmonoclonal antibody 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Plasma Cell Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Ixazomibsmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Plasma Cell Leukemia	2	Observed	clinicaltrials	graph →

Plasma Cell Leukemia investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 30show all (up to 200)

→ investigated in trials for

Fludarabinesmall molecule

9 trials (2 active) · roll-up of the cancer and its descendants

—

Plasma Cell Leukemia studied in …STUDIED_INderived10 of 53show all (up to 200)
→ studied in	NCT07605416Phase 2 · recruiting Testing an Experimental Approach to Treat Patients With Plasma Cell Leukemia, The QUANTUM Trial · condition mapped ONTOLOGY_EXACT · 53 trials mapped (28 active)	—	—	Plasma Cell Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07652905Phase 2 · recruiting CM336 Plus Isa-VR in Newly Diagnosed Primary Plasma Cell Leukemia · condition mapped ONTOLOGY_EXACT · 53 trials mapped (28 active)	—	—	Plasma Cell Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT03389347NA · completed High Throughput Drug Sensitivity and Genomics Data in Developing Individualized Treatment in Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell Leukemia · condition mapped ONTOLOGY_EXACT · 53 trials mapped (28 active)	—	—	Plasma Cell Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT05283993recruiting A Cohort Study of Plasma Cell Disorders (PCDs) in PKUFH · condition mapped ONTOLOGY_EXACT · 53 trials mapped (28 active)	—	—	Plasma Cell Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT06517017Phase 2 · recruiting Use of Isatuximab, Dexamethasone and Lenalidomide in a Go-Slow Fashion for Ultra-Frail Patients With Multiple Myeloma · condition mapped ONTOLOGY_EXACT · 53 trials mapped (28 active)	—	—	Plasma Cell Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT05092451Phase 1/Phase 2 · recruiting Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances · condition mapped ONTOLOGY_EXACT · 53 trials mapped (28 active)	—	—	Plasma Cell Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT06855121recruiting The Norwegian Immunotherapy in Multiple Myeloma Study · condition mapped ONTOLOGY_EXACT · 53 trials mapped (28 active)	—	—	Plasma Cell Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07649525Phase 3 · recruiting Personalising Treatment for Myeloma Patients Based on Initial Response to NHS Treatment and Their Overall Fitness Level · condition mapped ONTOLOGY_EXACT · 53 trials mapped (28 active)	—	—	Plasma Cell Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT05805605Phase 2 · recruiting Allo HSCT Using RIC and PTCy for Hematological Diseases · condition mapped ONTOLOGY_EXACT · 53 trials mapped (28 active)	—	—	Plasma Cell Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT05870917Phase 2 · active not recruiting A Study of VRD-based Regimen Combined With CART-ASCT-CART2 Treatment in Patients With Primary Plasma Cell Leukemia · condition mapped ONTOLOGY_EXACT · 53 trials mapped (28 active)	—	—	Plasma Cell Leukemia	1	Observed	clinicaltrials	graph →

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