Peripheral Primitive Neuroectodermal Tumor

subtype

Identifier: CI-CAN-00001406
Entity page: /cancer/peripheral-primitive-neuroectodermal-tumor ↗
Edges: 51

Neighbours: 16 drugs10 trials
Drawn: 26 of 26 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Peripheral Primitive Neuroectodermal Tumor investigated for …INVESTIGATED_FOR6 of 6
← investigated for	Vincristinesmall_molecule	unknown	2	Peripheral Primitive Neuroectodermal Tumor	1	Curated	chembl	graph →
← investigated for	Topotecansmall_molecule	unknown	2

Peripheral Primitive Neuroectodermal Tumor investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 24show all (up to 200)
→ investigated in trials for	Cyclophosphamidesmall_molecule 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Peripheral Primitive Neuroectodermal Tumor	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Vincristinesmall_molecule 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Peripheral Primitive Neuroectodermal Tumor	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal_antibody 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Peripheral Primitive Neuroectodermal Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Doxorubicinsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Peripheral Primitive Neuroectodermal Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Peripheral Primitive Neuroectodermal Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Ganitumabmonoclonal antibody 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Peripheral Primitive Neuroectodermal Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Ifosfamidesmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Peripheral Primitive Neuroectodermal Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Irinotecansmall_molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Peripheral Primitive Neuroectodermal Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Ivosidenibsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Peripheral Primitive Neuroectodermal Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Palbociclibsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Peripheral Primitive Neuroectodermal Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Samotolisibsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Peripheral Primitive Neuroectodermal Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Selpercatinibsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Peripheral Primitive Neuroectodermal Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Tazemetostatsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Peripheral Primitive Neuroectodermal Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Temozolomidesmall_molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Peripheral Primitive Neuroectodermal Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Tipifarnibsmall molecule 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	Peripheral Primitive Neuroectodermal Tumor	2	Observed	clinicaltrials	graph →

Peripheral Primitive Neuroectodermal Tumor investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 24show all (up to 200)

→ investigated in trials for

Cyclophosphamidesmall_molecule

3 trials (1 active) · roll-up of the cancer and its descendants

—

Peripheral Primitive Neuroectodermal Tumor

Observed

Peripheral Primitive Neuroectodermal Tumor studied in …STUDIED_INderived10 of 21show all (up to 200)
→ studied in	NCT06441331Phase 1 · recruiting Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors · condition mapped ONTOLOGY_EXACT · 21 trials mapped (9 active)	—	—	Peripheral Primitive Neuroectodermal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT03698994Phase 2 · active not recruiting Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) · condition mapped CURATED_BROADER · 21 trials mapped (9 active)	—	—	Peripheral Primitive Neuroectodermal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT04320888Phase 2 · active not recruiting Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial · condition mapped CURATED_BROADER · 21 trials mapped (9 active)	—	—	Peripheral Primitive Neuroectodermal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT02306161Phase 3 · active not recruiting Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma · condition mapped CURATED_BROADER · 21 trials mapped (9 active)	—	—	Peripheral Primitive Neuroectodermal Tumor of Bone	1	Observed	clinicaltrials	graph →
→ studied in	NCT03155620Phase 2 · active not recruiting Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial) · condition mapped CURATED_BROADER · 21 trials mapped (9 active)	—	—	Peripheral Primitive Neuroectodermal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT04284774Phase 2 · active not recruiting Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial · condition mapped CURATED_BROADER · 21 trials mapped (9 active)	—	—	Peripheral Primitive Neuroectodermal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT04195555Phase 2 · active not recruiting Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial) · condition mapped CURATED_BROADER · 21 trials mapped (9 active)	—	—	Peripheral Primitive Neuroectodermal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT04901702Phase 1/Phase 2 · recruiting Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma · condition mapped CURATED_BROADER · 21 trials mapped (9 active)	—	—	Peripheral Primitive Neuroectodermal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT06068075NA · active not recruiting Liquid Biopsy in Ewing Sarcoma and Osteosarcoma as a Prognostic And Response Diagnostic: LEOPARD · condition mapped ONTOLOGY_EXACT · 21 trials mapped (9 active)	—	—	Peripheral Primitive Neuroectodermal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT03213678Phase 2 · completed Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial) · condition mapped CURATED_BROADER · 21 trials mapped (9 active)	—	—	Peripheral Primitive Neuroectodermal Tumor	1	Observed	clinicaltrials	graph →

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