Megakaryocytic Neoplasm

hematologic malignancy

Identifier: CI-CAN-00001205
Entity page: /cancer/megakaryocytic-neoplasm ↗
Edges: 227

Neighbours: 16 drugs10 trials
Drawn: 26 of 26 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Megakaryocytic Neoplasm approved for …APPROVED_FORderived1 of 1
← approved for	Ropeginterferon Alfa-2bother FDA (US) · approved · 2021-11-12 · The treatment of adults with essential thrombocythemia.	—	approved	Essential Thrombocythemia	1	Regulatory	openfda	graph →
Megakaryocytic Neoplasm investigated in trials for …

Megakaryocytic Neoplasm studied in …STUDIED_INderived10 of 168show all (up to 200)
→ studied in	NCT05025488Phase 1 · active not recruiting Mutant CALR-peptide Based Vaccine in Patients With Mutated CALR Myeloproliferative Neoplasm · condition mapped ONTOLOGY_EXACT · 168 trials mapped (33 active)	—	—	Essential Thrombocythemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT04282187Phase 2 · recruiting Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms · condition mapped ONTOLOGY_EXACT · 168 trials mapped (33 active)	—	—	Essential Thrombocythemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT01831635completed Myeloproliferative Neoplasms: an In-depth Case-control Study · condition mapped ONTOLOGY_EXACT · 168 trials mapped (33 active)	—	—	Essential Thrombocythemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT06661915Phase 2 · recruiting A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs) · condition mapped ONTOLOGY_EXACT · 168 trials mapped (33 active)	—	—	Essential Thrombocythemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT02577926Phase 2 · active not recruiting The Ruxo-BEAT Trial in Patients With High-risk Polycythemia Vera or High-risk Essential Thrombocythemia · condition mapped ONTOLOGY_EXACT · 168 trials mapped (33 active)	—	—	Essential Thrombocythemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT06361641NA · recruiting Functional and Phenotypic Characterization of Monocytes in Myeloproliferative Syndromes · condition mapped ONTOLOGY_EXACT · 168 trials mapped (33 active)	—	—	Essential Thrombocythemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT00392353Phase 1/Phase 2 · active not recruiting Vorinostat and Azacitidine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia · condition mapped ONTOLOGY_EXACT · 168 trials mapped (33 active)	—	—	Acute Megakaryoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT02071901Phase 2 · completed Eltrombopag Olamine in Improving Platelet Recovery in Older Patients With Acute Myeloid Leukemia Undergoing Chemotherapy · condition mapped ONTOLOGY_EXACT · 168 trials mapped (33 active)	—	—	Adult Acute Megakaryoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT04285086Phase 3 · active not recruiting Ropeginterferon Alfa-2b (P1101) vs. Anagrelide in Essential Thrombocythemia Patients With Hydroxyurea Resistance or Intolerance · condition mapped ONTOLOGY_EXACT · 168 trials mapped (33 active)	—	—	Essential Thrombocythemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT03862157Phase 1/Phase 2 · active not recruiting Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia · condition mapped ONTOLOGY_EXACT · 168 trials mapped (33 active)	—	—	Essential Thrombocythemia	1	Observed	clinicaltrials	graph →

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