Leiomyosarcoma

subtype

Identifier: CI-CAN-00003020
Entity page: /cancer/leiomyosarcoma ↗
Edges: 215

Neighbours: 30 drugs10 trials
Drawn: 40 of 40 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Leiomyosarcoma investigated for …INVESTIGATED_FOR24 of 24show fewer
← investigated for	Trabectedinsmall_molecule	unknown	4	Leiomyosarcoma	1	Curated	chembl	graph →
← investigated for	Ifosfamidesmall_molecule	unknown	3

Leiomyosarcoma investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 56show all (up to 200)
→ investigated in trials for	Doxorubicinsmall_molecule 15 trials (6 active) · roll-up of the cancer and its descendants	—	—	Leiomyosarcoma	15	Observed	clinicaltrials	graph →
→ investigated in trials for	Gemcitabinesmall_molecule 13 trials (3 active) · roll-up of the cancer and its descendants	—	—	Leiomyosarcoma	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Trabectedinsmall_molecule 10 trials (4 active) · roll-up of the cancer and its descendants	—	—	Leiomyosarcoma	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Docetaxelsmall_molecule 9 trials (1 active) · roll-up of the cancer and its descendants	—	—	Leiomyosarcoma	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal_antibody 6 trials (4 active) · roll-up of the cancer and its descendants	—	—	Leiomyosarcoma	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Ifosfamidesmall_molecule 5 trials (2 active) · roll-up of the cancer and its descendants	—	—	Leiomyosarcoma	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Dacarbazinesmall_molecule 4 trials (1 active) · roll-up of the cancer and its descendants	—	—	Leiomyosarcoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Pazopanibsmall_molecule 4 trials (1 active) · roll-up of the cancer and its descendants	—	—	Leiomyosarcoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal_antibody 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Leiomyosarcoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Cixutumumabmonoclonal antibody 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Leiomyosarcoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Eribulinsmall molecule 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Leiomyosarcoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Filgrastimother 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Leiomyosarcoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Pegfilgrastimother 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Leiomyosarcoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Pembrolizumabmonoclonal antibody 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Leiomyosarcoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Alisertibsmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Leiomyosarcoma	2	Observed	clinicaltrials	graph →

Leiomyosarcoma investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 56show all (up to 200)

→ investigated in trials for

Doxorubicinsmall_molecule

15 trials (6 active) · roll-up of the cancer and its descendants

—

Leiomyosarcoma

Observed

Leiomyosarcoma studied in …STUDIED_INderived10 of 135show all (up to 200)
→ studied in	NCT06498648Phase 1/Phase 2 · recruiting Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma · condition mapped CURATED_BROADER · 135 trials mapped (45 active)	—	—	Leiomyosarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06524583Phase 2 · recruiting Interest of Post-operative Chemotherapy in Patients With Localised Uterine Leiomyosarcoma Suspected of Having a High Risk of Recurrence Based on a Biological Test Performed on the Tumour · condition mapped ALIAS · 135 trials mapped (45 active)	—	—	Uterine Corpus Leiomyosarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02923778Phase 2 · active not recruiting Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery · condition mapped ONTOLOGY_EXACT · 135 trials mapped (45 active)	—	—	Leiomyosarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06308419Phase 1 · active not recruiting A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions · condition mapped ONTOLOGY_EXACT · 135 trials mapped (45 active)	—	—	Leiomyosarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04031677Phase 3 · recruiting Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma · condition mapped ONTOLOGY_EXACT · 135 trials mapped (45 active)	—	—	Leiomyosarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05711615Phase 1 · recruiting Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma · condition mapped CURATED_BROADER · 135 trials mapped (45 active)	—	—	Leiomyosarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05099666Phase 1/Phase 2 · active not recruiting Lurbinectedin + Doxorubicin In Leiomyosarcoma · condition mapped CURATED_BROADER · 135 trials mapped (45 active)	—	—	Leiomyosarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07516925Phase 2 · recruiting A Study of Ivonescimab in People With Leiomyosarcoma · condition mapped ONTOLOGY_EXACT · 135 trials mapped (45 active)	—	—	Leiomyosarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06975293Phase 1/Phase 2 · recruiting STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected Sarcomas · condition mapped ONTOLOGY_EXACT · 135 trials mapped (45 active)	—	—	Leiomyosarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05827614Phase 1 · terminated Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene Amplifications · condition mapped ONTOLOGY_EXACT · 135 trials mapped (45 active)	—	—	Leiomyosarcoma	1	Observed	clinicaltrials	graph →

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