Digestive System Neuroendocrine Tumor

subtype

Identifier: CI-CAN-00000823
Entity page: /cancer/digestive-system-neuroendocrine-tumor ↗
Edges: 327

Neighbours: 4 genes1 variants18 drugs10 trials
Drawn: 33 of 33 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Digestive System Neuroendocrine Tumor predicts response to …PREDICTS_RESPONSE_TO3 of 3
in context · predicts response to	BRAF V600ESNV → predicts response to Vemurafenib	sensitivity	C	Digestive System Neuroendocrine Tumor	1	Curated	civic	graph →
in context · predicts response to

Digestive System Neuroendocrine Tumor associated with …ASSOCIATED_WITH1 of 1
← associated with	BRAF	supports	C	Digestive System Neuroendocrine Tumor	1	Curated	civic	graph →

Digestive System Neuroendocrine Tumor associated with …ASSOCIATED_WITH1 of 1

← associated with

BRAF

supports

Digestive System Neuroendocrine Tumor

Curated

Digestive System Neuroendocrine Tumor investigated for …INVESTIGATED_FOR3 of 3
← investigated for	Vemurafenibsmall_molecule	supports	C	Digestive System Neuroendocrine Tumor	1	Curated	civic	graph →
← investigated for	Dabrafenibsmall_molecule	supports	C	Digestive System Neuroendocrine Tumor	1	Curated	civic	graph →
← investigated for	Trametinibsmall_molecule	supports	C	Digestive System Neuroendocrine Tumor	1	Curated	civic	graph →

Digestive System Neuroendocrine Tumor altered in cohorts of …ALTERED_INderived3 of 3
← altered in cohorts of	MEN1 36 / 98 cases (37 %) · ssm · panet_arcnet_2017 · largest of 2 cohorts	—	—	Pancreatic Neuroendocrine Tumor	2	Observed	cbioportal	graph →
← altered in cohorts of	DAXX 22 / 98 cases (22 %) · ssm · panet_arcnet_2017 · largest of 2 cohorts	—	—	Pancreatic Neuroendocrine Tumor	2	Observed	cbioportal	graph →
← altered in cohorts of	ATRX 21 / 96 cases (22 %) · ssm · panet_msk_2018	—	—	Pancreatic Neuroendocrine Tumor	1	Observed	cbioportal	graph →

Digestive System Neuroendocrine Tumor investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 61show all (up to 200)
→ investigated in trials for	Everolimussmall molecule 17 trials (4 active) · roll-up of the cancer and its descendants	—	—	Digestive System Neuroendocrine Tumor	17	Observed	clinicaltrials	graph →
→ investigated in trials for	Lutetium (177lu) Oxodotreotideother 9 trials (7 active) · roll-up of the cancer and its descendants	—	—	Digestive System Neuroendocrine Tumor	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Temozolomidesmall molecule 9 trials (2 active) · roll-up of the cancer and its descendants	—	—	Digestive System Neuroendocrine Tumor	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Cabozantinibsmall molecule 8 trials (6 active) · roll-up of the cancer and its descendants	—	—	Digestive System Neuroendocrine Tumor	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Sunitinibsmall molecule 8 trials (3 active) · roll-up of the cancer and its descendants	—	—	Digestive System Neuroendocrine Tumor	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 7 trials (2 active) · roll-up of the cancer and its descendants	—	—	Digestive System Neuroendocrine Tumor	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Capecitabinesmall molecule 7 trials (2 active) · roll-up of the cancer and its descendants	—	—	Digestive System Neuroendocrine Tumor	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Irinotecansmall molecule 6 trials (0 active) · roll-up of the cancer and its descendants	—	—	Digestive System Neuroendocrine Tumor	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal antibody 6 trials (3 active) · roll-up of the cancer and its descendants	—	—	Digestive System Neuroendocrine Tumor	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Fluorouracilsmall molecule 5 trials (0 active) · roll-up of the cancer and its descendants	—	—	Digestive System Neuroendocrine Tumor	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Temsirolimussmall molecule 4 trials (0 active) · roll-up of the cancer and its descendants	—	—	Digestive System Neuroendocrine Tumor	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Carboplatinsmall molecule 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Digestive System Neuroendocrine Tumor	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Cisplatinsmall molecule 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Digestive System Neuroendocrine Tumor	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall molecule 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Digestive System Neuroendocrine Tumor	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumabmonoclonal antibody 3 trials (2 active) · roll-up of the cancer and its descendants	—	—	Digestive System Neuroendocrine Tumor	3	Observed	clinicaltrials	graph →

Digestive System Neuroendocrine Tumor studied in …STUDIED_INderived10 of 256show all (up to 200)
→ studied in	NCT01824875Phase 2 · completed Temozolomide With or Without Capecitabine in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors · condition mapped ALIAS · 256 trials mapped (80 active)	—	—	Gastrin-Producing Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT03866382Phase 2 · recruiting Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors · condition mapped ONTOLOGY_EXACT · 256 trials mapped (80 active)	—	—	Bladder Small Cell Neuroendocrine Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06479811Phase 1 · recruiting [212Pb]VMT-Alpha-NET in Metastatic or Inoperable Somatostatin-Receptor Positive Gastrointestinal Neuroendocrine Tumors, Pheochromocytoma/Paragangliomas, Small Cell Lung, Renal Cell, and Head and Neck Cancers · condition mapped ALIAS · 256 trials mapped (80 active)	—	—	Digestive System Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT06943755Phase 2/Phase 3 · recruiting Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors · condition mapped ONTOLOGY_EXACT · 256 trials mapped (80 active)	—	—	Pancreatic Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT00001276recruiting Diagnosing and Treating Low Blood Sugar Levels · condition mapped ALIAS · 256 trials mapped (80 active)	—	—	Pancreatic Insulinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05196087recruiting Non-Invasive Artificial Intelligence-Based Platform MonIToring Program (NIP IT!) · condition mapped ALIAS · 256 trials mapped (80 active)	—	—	Digestive System Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT04924075Phase 2 · recruiting Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015) · condition mapped ONTOLOGY_EXACT · 256 trials mapped (80 active)	—	—	Pancreatic Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT05773274Phase 2 · recruiting Comparing Retreatment of 177Lu-DOTATATE PRRT Versus the Usual Treatment in Patients With Metastatic Unresectable Gastroenteropancreatic Neuroendocrine Tumors, NET RETREAT Trial · condition mapped CURATED_BROADER · 256 trials mapped (80 active)	—	—	Digestive System Neuroendocrine Tumor G1	1	Observed	clinicaltrials	graph →
→ studied in	NCT03967951completed CT Radiomic Features of Pancreatic Neuroendocrine Neoplasms · condition mapped ONTOLOGY_EXACT · 256 trials mapped (80 active)	—	—	Pancreatic Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT03375320Phase 3 · active not recruiting Testing Cabozantinib in Patients With Advanced Pancreatic Neuroendocrine and Carcinoid Tumors · condition mapped ONTOLOGY_EXACT · 256 trials mapped (80 active)	—	—	Functioning Pancreatic Neuroendocrine Tumor	1	Observed	clinicaltrials	graph →

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