Diffuse Intrinsic Pontine Glioma

subtype

Identifier: CI-CAN-00005106
Entity page: /cancer/diffuse-intrinsic-pontine-glioma ↗
Edges: 176

Neighbours: 28 drugs10 trials
Drawn: 38 of 38 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Diffuse Intrinsic Pontine Glioma investigated for …INVESTIGATED_FOR25 of 25show fewer
← investigated for	Temozolomidesmall_molecule	unknown	3	Diffuse Intrinsic Pontine Glioma	1	Curated	chembl	graph →
← investigated for	Nimotuzumabmonoclonal_antibody	unknown	3

Diffuse Intrinsic Pontine Glioma investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 40show all (up to 200)
→ investigated in trials for	Temozolomidesmall_molecule 10 trials (5 active) · roll-up of the cancer and its descendants	—	—	Diffuse Intrinsic Pontine Glioma	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Everolimussmall_molecule 6 trials (2 active) · roll-up of the cancer and its descendants	—	—	Diffuse Intrinsic Pontine Glioma	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal_antibody 5 trials (2 active) · roll-up of the cancer and its descendants	—	—	Diffuse Intrinsic Pontine Glioma	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 4 trials (2 active) · roll-up of the cancer and its descendants	—	—	Diffuse Intrinsic Pontine Glioma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Irinotecansmall_molecule 4 trials (2 active) · roll-up of the cancer and its descendants	—	—	Diffuse Intrinsic Pontine Glioma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Ribociclibsmall_molecule 4 trials (1 active) · roll-up of the cancer and its descendants	—	—	Diffuse Intrinsic Pontine Glioma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Dordavipronesmall_molecule 3 trials (2 active) · roll-up of the cancer and its descendants	—	—	Diffuse Intrinsic Pontine Glioma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall molecule 3 trials (2 active) · roll-up of the cancer and its descendants	—	—	Diffuse Intrinsic Pontine Glioma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal_antibody 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Diffuse Intrinsic Pontine Glioma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Panobinostatsmall_molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Diffuse Intrinsic Pontine Glioma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Dasatinibsmall_molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Diffuse Intrinsic Pontine Glioma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Erlotinibsmall_molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Diffuse Intrinsic Pontine Glioma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Gemcitabinesmall_molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Diffuse Intrinsic Pontine Glioma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Nimotuzumabmonoclonal_antibody 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Diffuse Intrinsic Pontine Glioma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Topotecansmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Diffuse Intrinsic Pontine Glioma	2	Observed	clinicaltrials	graph →

Diffuse Intrinsic Pontine Glioma investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 40show all (up to 200)

→ investigated in trials for

Temozolomidesmall_molecule

10 trials (5 active) · roll-up of the cancer and its descendants

—

Diffuse Intrinsic Pontine Glioma studied in …STUDIED_INderived10 of 111show all (up to 200)
→ studied in	NCT01445288completed Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors · condition mapped ONTOLOGY_EXACT · 111 trials mapped (52 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04837547Phase 1 · active not recruiting PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy · condition mapped ONTOLOGY_EXACT · 111 trials mapped (52 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06838676Phase 2 · recruiting ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas · condition mapped ALIAS · 111 trials mapped (52 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04870944Phase 1/Phase 2 · recruiting CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma · condition mapped CURATED_BROADER · 111 trials mapped (52 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06639607Phase 1/Phase 2 · suspended PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma · condition mapped PROBABILISTIC · 111 trials mapped (52 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06946680Phase 1 · not yet recruiting IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG) · condition mapped ONTOLOGY_EXACT · 111 trials mapped (52 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07644312Phase 2 · not yet recruiting Study of Relatlimab and Nivolumab (Opdualag) in Replication Repair Deficient HGG and DIPG · condition mapped ONTOLOGY_EXACT · 111 trials mapped (52 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05839379recruiting Targeted Pediatric High-Grade Glioma Therapy · condition mapped ONTOLOGY_EXACT · 111 trials mapped (52 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06465199Phase 1/Phase 2 · recruiting Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas · condition mapped ONTOLOGY_EXACT · 111 trials mapped (52 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06161974Phase 2 · recruiting Study of Olutasidenib and Temozolomide in HGG · condition mapped ONTOLOGY_EXACT · 111 trials mapped (52 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →

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