Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive

molecular subtype

Identifier: CI-CAN-00004951
Entity page: /cancer/chronic-myeloid-leukemia-philadelphia-chromosome-negative-bcr-abl1-positive ↗
Edges: 28

Neighbours: 15 drugs10 trials
Drawn: 25 of 25 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive approved for …APPROVED_FOR5 of 5
← approved for	Nilotinibsmall_molecule 4 source records aggregated	supports	FDA ORIG	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	4	Regulatory	openfda	graph →
← approved for	Bosutinib

Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive investigated in trials for …INVESTIGATED_IN_TRIALSderived13 of 13
→ investigated in trials for	Fludarabinesmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Asciminibsmall_molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Azacitidinesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Belinostatsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Bosutinibsmall_molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Busulfansmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Carboplatinsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Decitabinesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Sorafenib Tosylatesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Topotecansmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Veliparibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Vorinostatsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →

Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive investigated in trials for …INVESTIGATED_IN_TRIALSderived13 of 13

→ investigated in trials for

Fludarabinesmall molecule

2 trials (0 active) · roll-up of the cancer and its descendants

—

Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive

Observed

Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive studied in …STUDIED_INderived10 of 10
→ studied in	NCT07814560not yet recruiting Metabolic Syndrome and Risk of Chronic Philadelphia Negative Myeloproliferative Neoplasms · condition mapped ALIAS · 10 trials mapped (1 active)	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ studied in	NCT04216563Phase 2 · terminated ABL001 for the Treatment of Chronic Myeloid Leukemia in Patients Who Are on Therapy With Tyrosine Kinase Inhibitor · condition mapped ALIAS · 10 trials mapped (1 active)	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ studied in	NCT00588991Phase 1 · completed Veliparib and Topotecan With or Without Carboplatin in Treating Patients With Relapsed or Refractory Acute Leukemia, High-Risk Myelodysplasia, or Aggressive Myeloproliferative Disorders · condition mapped ONTOLOGY_EXACT · 10 trials mapped (1 active)	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ studied in	NCT02228382Phase 4 · terminated Safety And Efficacy Study Of Bosutinib In Patients With Philadelphia Chromosome Positive Chronic Myeloid Leukemia Previously Treated With One Or More Tyrosine Kinase Inhibitors · condition mapped CURATED_BROADER · 10 trials mapped (1 active)	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ studied in	NCT01445080Phase 1/Phase 2 · completed Sorafenib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Leukemia · condition mapped ALIAS · 10 trials mapped (1 active)	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ studied in	NCT01427881Phase 2 · completed Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies · condition mapped ALIAS · 10 trials mapped (1 active)	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ studied in	NCT00381550Phase 2 · completed 3-AP and Fludarabine in Treating Patients With Myeloproliferative Disorders, Chronic Myelomonocytic Leukemia, or Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemia · condition mapped ALIAS · 10 trials mapped (1 active)	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ studied in	NCT00351975Phase 1 · completed Belinostat and Azacitidine in Treating Patients With Advanced Hematologic Cancers or Other Diseases · condition mapped ALIAS · 10 trials mapped (1 active)	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ studied in	NCT00807677Phase 1 · completed A Phase 1 Dose Escalation Study of TAK-901 in Subjects With Advanced Hematologic Malignancies · condition mapped ALIAS · 10 trials mapped (1 active)	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ studied in	NCT00357708Phase 1 · completed Vorinostat and Decitabine in Treating Patients With Relapsed, Refractory, or Poor-Prognosis Hematologic Cancer or Other Diseases · condition mapped ALIAS · 10 trials mapped (1 active)	—	—	Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →

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