Childhood Nervous System Neoplasm

cancer family

Identifier: CI-CAN-00000136
Entity page: /cancer/childhood-nervous-system-neoplasm ↗
Edges: 302

Neighbours: 15 drugs10 trials
Drawn: 25 of 25 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Childhood Nervous System Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 78show all (up to 200)
→ investigated in trials for	Temozolomidesmall molecule 19 trials (5 active) · roll-up of the cancer and its descendants	—	—	Childhood Nervous System Neoplasm	19	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamide

Paths

Strongest chains

Gene → variant → drug chains anchored in this cancer (or a descendant), ranked by source-native evidence level then support, with the approval and trial registry hops when they exist.

BRAF Fusion Tovorafenib1 active / 1 trials
Curatedlevel Asensitivity· support 1civicObservedcohort frequency not yet available for BRAF in this cancerno approval record in this cancercontext: Childhood Low Grade Glioma
BRAF Fusion Tovorafenib1 active / 1 trials
Curatedlevel Asensitivity· support 1civicObservedcohort frequency not yet available for BRAF in this cancerno approval record in this cancercontext: Childhood Low Grade Glioma
BRAF V600 Tovorafenib1 active / 1 trials
Curatedlevel Asensitivity· support 1civicObservedcohort frequency not yet available for BRAF in this cancerno approval record in this cancercontext: Childhood Low Grade Glioma
BRAF V600E Tovorafenib1 active / 1 trials
Curatedlevel Asensitivity· support 1civicObservedcohort frequency not yet available for BRAF in this cancerno approval record in this cancercontext: Childhood Low Grade Glioma
ERBB2 Amplification Lapatinib0 active / 1 trials
Curatedlevel Bsensitivity· support 1civicObservedcohort frequency not yet available for ERBB2 in this cancerno approval record in this cancercontext: Childhood Ependymoma
NF1 Mutation Selumetinib1 active / 2 trials
Curatedlevel Bsensitivity· support 1civicObservedcohort frequency not yet available for NF1 in this cancerno approval record in this cancercontext: Childhood Low Grade Glioma
BRAF V600E Vemurafenib0 active / 1 trials
Curatedlevel Csensitivity· support 1civicObservedcohort frequency not yet available for BRAF in this cancerno approval record in this cancercontext: Childhood Pilocytic Astrocytoma
ROS1 Fusion EntrectinibEMA EU 2020-07-310 active / 0 trials
Curatedlevel Csensitivity· support 1civicObservedcohort frequency not yet available for ROS1 in this cancerRegulatoryapproved for Lung Non-Small Cell Carcinoma (3 approval records)context: Desmoplastic Infantile Astrocytoma

Each hop keeps its own claim category: cohort alteration frequency (observed, cases ≥ 20), CIViC predictive edge (curated, level as stated by CIViC), regulatory approval (authority, jurisdiction, date as published), trial count (registry). A missing hop is shown as missing — never filled in. Not treatment guidance.

Childhood Nervous System Neoplasm studied in …STUDIED_INderived10 of 224show all (up to 200)
→ studied in	NCT07346157Phase 1/Phase 2 · recruiting Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease · condition mapped ONTOLOGY_EXACT · 224 trials mapped (71 active)	—	—	Childhood Medulloblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02573441NA · completed KEYS to Succeed: Cognitive and Academic Intervention Program for Children and Adolescents Surviving Cancer · condition mapped ALIAS · 224 trials mapped (71 active)	—	—	Childhood Brain Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05230758Phase 3 · recruiting Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour · condition mapped ONTOLOGY_EXACT · 224 trials mapped (71 active)	—	—	Childhood Medulloblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05367076NA · completed Fitness to Aid the Brain and Cognitive Skills · condition mapped ALIAS · 224 trials mapped (71 active)	—	—	Childhood Brain Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07830134NA · recruiting Cognitive Rehabilitation for Survivors of Childhood Medulloblastoma Using Real Time Hemodynamic Neurofeedback · condition mapped ONTOLOGY_EXACT · 224 trials mapped (71 active)	—	—	Childhood Medulloblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03210714Phase 2 · active not recruiting Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial) · condition mapped CURATED_BROADER · 224 trials mapped (71 active)	—	—	Childhood Ependymoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01089101Phase 1/Phase 2 · active not recruiting Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma · condition mapped CURATED_BROADER · 224 trials mapped (71 active)	—	—	Childhood Pilocytic Astrocytoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07558395NA · not yet recruiting Effectiveness of a Visual Telerehabilitation Program on Visual Perception in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour · condition mapped ALIAS · 224 trials mapped (71 active)	—	—	Childhood Brain Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06357377Phase 1 · recruiting A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors · condition mapped ALIAS · 224 trials mapped (71 active)	—	—	Childhood Central Nervous System Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07819838Phase 1/Phase 2 · not yet recruiting Testing the Addition of an Anti-Cancer Drug, Daraxonrasib, for Relapsed or Refractory Solid Tumors With RAS Mutations · condition mapped CURATED_BROADER · 224 trials mapped (71 active)	—	—	Childhood Neuroblastoma	1	Observed	clinicaltrials	graph →