Childhood Low Grade Glioma

subtype

Identifier: CI-CAN-00004877
Entity page: /cancer/childhood-low-grade-glioma ↗
Edges: 110

Neighbours: 8 genes11 variants17 drugs10 trials
Drawn: 46 of 46 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Childhood Low Grade Glioma predicts response to …PREDICTS_RESPONSE_TO7 of 7
in context · predicts response to	BRAF Fusionfusion → predicts response to Tovorafenib	sensitivity	A	Childhood Low Grade Glioma	1	Curated	civic	graph →
in context · predicts response to

Paths

Strongest chains

Gene → variant → drug chains anchored in this cancer (or a descendant), ranked by source-native evidence level then support, with the approval and trial registry hops when they exist.

BRAF Fusion Tovorafenib1 active / 1 trials
Curatedlevel Asensitivity· support 1civicObservedcohort frequency not yet available for BRAF in this cancerno approval record in this cancercontext: Childhood Low Grade Glioma
BRAF Fusion Tovorafenib1 active / 1 trials
Curatedlevel Asensitivity· support 1civicObservedcohort frequency not yet available for BRAF in this cancerno approval record in this cancercontext: Childhood Low Grade Glioma
BRAF V600 Tovorafenib1 active / 1 trials
Curatedlevel Asensitivity· support 1civicObservedcohort frequency not yet available for BRAF in this cancerno approval record in this cancercontext: Childhood Low Grade Glioma
BRAF V600E Tovorafenib1 active / 1 trials
Curatedlevel Asensitivity· support 1civicObservedcohort frequency not yet available for BRAF in this cancerno approval record in this cancercontext: Childhood Low Grade Glioma
ERBB2 Amplification Lapatinib0 active / 1 trials
Curatedlevel Bsensitivity· support 1civicObservedcohort frequency not yet available for ERBB2 in this cancerno approval record in this cancercontext: Childhood Ependymoma
NF1 Mutation Selumetinib1 active / 1 trials
Curatedlevel Bsensitivity· support 1civicObservedcohort frequency not yet available for NF1 in this cancerno approval record in this cancercontext: Childhood Low Grade Glioma
BRAF V600E Vemurafenib0 active / 0 trials
Curatedlevel Csensitivity· support 1civicObservedcohort frequency not yet available for BRAF in this cancerno approval record in this cancercontext: Childhood Pilocytic Astrocytoma
BRAF Fusion TrametinibFDA US 2013-05-29 · tumour-agnostic1 active / 2 trials
Curatedlevel Dsensitivity· support 2civicObservedcohort frequency not yet available for BRAF in this cancerRegulatoryapproved (2 approval records)context: Childhood Low Grade Glioma, Childhood Pilocytic Astrocytoma

Each hop keeps its own claim category: cohort alteration frequency (observed, cases ≥ 20), CIViC predictive edge (curated, level as stated by CIViC), regulatory approval (authority, jurisdiction, date as published), trial count (registry). A missing hop is shown as missing — never filled in. Not treatment guidance.

Childhood Low Grade Glioma prognostic in …PROGNOSTIC_IN7 of 7
← prognostic in	BRAF Fusionfusion 2 source records aggregated	supports	B	Childhood Low Grade Glioma	2	Curated	civic	graph →
← prognostic in	MYB AMPLIFICATIONamplification	supports	B	Childhood Low Grade Glioma	1	Curated	civic	graph →
← prognostic in	CDKN2A Deletiondeletion_cna	supports	B	Childhood Low Grade Glioma	1	Curated	civic	graph →
← prognostic in	BRAF V600ESNV	supports	B	Childhood Low Grade Glioma	1	Curated	civic	graph →
← prognostic in	ATRX Underexpressionexpression	supports	B	Childhood Low Grade Glioma	1	Curated	civic	graph →
← prognostic in	H3-3A MUTATIONother	supports	B	Childhood Low Grade Glioma	1	Curated	civic	graph →
← prognostic in	TERT Promoter Mutationpromoter_mutation	supports	C	Childhood Low Grade Glioma	1	Curated	civic	graph →

Childhood Low Grade Glioma diagnostic of …DIAGNOSTIC_OF1 of 1
← diagnostic of	FGFR1 Internal Duplicationinsertion	supports	B	Childhood Low Grade Glioma	1	Curated	civic	graph →

Childhood Low Grade Glioma associated with …ASSOCIATED_WITH10 of 10
← associated with	BRAF 2 source records aggregated	supports	A	Childhood Low Grade Glioma	2	Curated	civic	graph →
← associated with	BRAF 3 source records aggregated	supports	B	Childhood Low Grade Glioma	3	Curated	civic	graph →
← associated with	NF1	supports	B	Childhood Low Grade Glioma	1	Curated	civic	graph →
← associated with	FGFR1	supports	B	Childhood Low Grade Glioma	1	Curated	civic	graph →
← associated with	MYB	supports	B	Childhood Low Grade Glioma	1	Curated	civic	graph →
← associated with	CDKN2A	supports	B	Childhood Low Grade Glioma	1	Curated	civic	graph →
← associated with	ATRX	supports	B	Childhood Low Grade Glioma	1	Curated	civic	graph →
← associated with	H3-3A	supports	B	Childhood Low Grade Glioma	1	Curated	civic	graph →
← associated with	TERT	supports	C	Childhood Low Grade Glioma	1	Curated	civic	graph →
← associated with	BRAF	supports	D	Childhood Low Grade Glioma	1	Curated	civic	graph →

Childhood Low Grade Glioma investigated for …INVESTIGATED_FOR4 of 4
← investigated for	Tovorafenibsmall_molecule 2 source records aggregated	supports	A	Childhood Low Grade Glioma	2	Curated	civic	graph →
← investigated for	Selumetinibsmall_molecule	supports	B	Childhood Low Grade Glioma	1	Curated	civic	graph →
← investigated for	Everolimussmall_molecule	supports	D	Childhood Low Grade Glioma	1	Curated	civic	graph →
← investigated for	Trametinibsmall_molecule	supports	D	Childhood Low Grade Glioma	1	Curated	civic	graph →

Childhood Low Grade Glioma investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 37show all (up to 200)
→ investigated in trials for	Temozolomidesmall molecule 5 trials (0 active) · roll-up of the cancer and its descendants	—	—	Childhood Low Grade Glioma	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Irinotecansmall molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Childhood Low Grade Glioma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Dabrafenibsmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Childhood Low Grade Glioma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Everolimussmall_molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Childhood Low Grade Glioma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Filgrastimother 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Childhood Low Grade Glioma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Lenalidomidesmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Childhood Low Grade Glioma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Oxaliplatinsmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Childhood Low Grade Glioma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Topotecansmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Childhood Low Grade Glioma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Trametinibsmall_molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Childhood Low Grade Glioma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Veliparibsmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Childhood Low Grade Glioma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Vorinostatsmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Childhood Low Grade Glioma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Alvocidibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Childhood Low Grade Glioma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Azacitidinesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Childhood Low Grade Glioma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Childhood Low Grade Glioma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Bortezomibsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	Childhood Low Grade Glioma	1	Observed	clinicaltrials	graph →

Childhood Low Grade Glioma studied in …STUDIED_INderived10 of 44show all (up to 200)
→ studied in	NCT03210714Phase 2 · active not recruiting Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial) · condition mapped CURATED_BROADER · 44 trials mapped (7 active)	—	—	Childhood Ependymoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01089101Phase 1/Phase 2 · active not recruiting Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma · condition mapped CURATED_BROADER · 44 trials mapped (7 active)	—	—	Childhood Pilocytic Astrocytoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03975829Phase 4 · active not recruiting Pediatric Long-Term Follow-up and Rollover Study · condition mapped ONTOLOGY_EXACT · 44 trials mapped (7 active)	—	—	Childhood Oligodendroglioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05857969Phase 1 · recruiting Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling · condition mapped CURATED_BROADER · 44 trials mapped (7 active)	—	—	Childhood Ependymoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06666348Phase 1/Phase 2 · recruiting Phase 1/2 Study of Mirdametinib + Vinblastine for Newly Diagnosed/Previously Untreated PLGG + Activation of MAPK · condition mapped ALIAS · 44 trials mapped (7 active)	—	—	Childhood Low Grade Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02359565Phase 1 · active not recruiting Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma · condition mapped CURATED_BROADER · 44 trials mapped (7 active)	—	—	Childhood Ependymoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05566795Phase 3 · active not recruiting DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2) · condition mapped ALIAS · 44 trials mapped (7 active)	—	—	Childhood Low Grade Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03526250Phase 2 · completed Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial) · condition mapped CURATED_BROADER · 44 trials mapped (7 active)	—	—	Childhood Ependymoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00638898Phase 1 · completed Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor · condition mapped CURATED_BROADER · 44 trials mapped (7 active)	—	—	Childhood Ependymoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01553149Phase 2 · completed Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma · condition mapped CURATED_BROADER · 44 trials mapped (7 active)	—	—	Childhood Pilocytic Astrocytoma	1	Observed	clinicaltrials	graph →