Brain Stem Neoplasm

subtype

Identifier: CI-CAN-00007342
Entity page: /cancer/brain-stem-neoplasm ↗
Edges: 261

Neighbours: 17 drugs10 trials
Drawn: 27 of 27 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Brain Stem Neoplasm investigated for …INVESTIGATED_FOR4 of 4
← investigated for	Thalidomidesmall_molecule	unknown	2	Brain Stem Neoplasm	1	Curated	chembl	graph →
← investigated for	Temozolomidesmall_molecule	unknown	2

Brain Stem Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 67show all (up to 200)
→ investigated in trials for	Temozolomidesmall_molecule 19 trials (5 active) · roll-up of the cancer and its descendants	—	—	Brain Stem Neoplasm	19	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 8 trials (2 active) · roll-up of the cancer and its descendants	—	—	Brain Stem Neoplasm	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Everolimussmall molecule 7 trials (2 active) · roll-up of the cancer and its descendants	—	—	Brain Stem Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Irinotecansmall molecule 6 trials (2 active) · roll-up of the cancer and its descendants	—	—	Brain Stem Neoplasm	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 5 trials (3 active) · roll-up of the cancer and its descendants	—	—	Brain Stem Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Vorinostatsmall molecule 5 trials (0 active) · roll-up of the cancer and its descendants	—	—	Brain Stem Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Ribociclibsmall molecule 4 trials (1 active) · roll-up of the cancer and its descendants	—	—	Brain Stem Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Dasatinibsmall molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Brain Stem Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Dordavipronesmall molecule 3 trials (2 active) · roll-up of the cancer and its descendants	—	—	Brain Stem Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall molecule 3 trials (2 active) · roll-up of the cancer and its descendants	—	—	Brain Stem Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Nimotuzumabmonoclonal_antibody 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Brain Stem Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal antibody 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Brain Stem Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Oxaliplatinsmall molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Brain Stem Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Panobinostatsmall molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Brain Stem Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Topotecansmall molecule 3 trials (1 active) · roll-up of the cancer and its descendants	—	—	Brain Stem Neoplasm	3	Observed	clinicaltrials	graph →

Brain Stem Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 67show all (up to 200)

→ investigated in trials for

Temozolomidesmall_molecule

19 trials (5 active) · roll-up of the cancer and its descendants

—

Brain Stem Neoplasm

Observed

Brain Stem Neoplasm studied in …STUDIED_INderived10 of 190show all (up to 200)
→ studied in	NCT01445288completed Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors · condition mapped ONTOLOGY_EXACT · 190 trials mapped (62 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04837547Phase 1 · active not recruiting PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy · condition mapped ONTOLOGY_EXACT · 190 trials mapped (62 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06838676Phase 2 · recruiting ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas · condition mapped ALIAS · 190 trials mapped (62 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06357377Phase 1 · recruiting A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors · condition mapped ALIAS · 190 trials mapped (62 active)	—	—	Childhood Brain Stem Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04870944Phase 1/Phase 2 · recruiting CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma · condition mapped CURATED_BROADER · 190 trials mapped (62 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06639607Phase 1/Phase 2 · suspended PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma · condition mapped PROBABILISTIC · 190 trials mapped (62 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06946680Phase 1 · not yet recruiting IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG) · condition mapped ONTOLOGY_EXACT · 190 trials mapped (62 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07644312Phase 2 · not yet recruiting Study of Relatlimab and Nivolumab (Opdualag) in Replication Repair Deficient HGG and DIPG · condition mapped ONTOLOGY_EXACT · 190 trials mapped (62 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05839379recruiting Targeted Pediatric High-Grade Glioma Therapy · condition mapped ONTOLOGY_EXACT · 190 trials mapped (62 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06465199Phase 1/Phase 2 · recruiting Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas · condition mapped ONTOLOGY_EXACT · 190 trials mapped (62 active)	—	—	Diffuse Intrinsic Pontine Glioma	1	Observed	clinicaltrials	graph →

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