Biliary Tract Carcinoma

subtype

Identifier: CI-CAN-00001970
Entity page: /cancer/biliary-tract-carcinoma ↗
Edges: 1,074

Neighbours: 15 genes17 drugs10 trials
Drawn: 42 of 42 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Biliary Tract Carcinoma approved for …APPROVED_FOR6 of 5
← approved for	Pembrolizumabmonoclonal_antibody	supports	EMA indication text	Biliary Tract Carcinoma	1	Regulatory	ema	graph →
← approved for	Futibatinibsmall molecule EMA (EU) · approved · 2023-07-04 · Lytgobi monotherapy is indicated for the treatment of adult patients with locally advanced or metastatic cholangiocarcinoma with a fibrobla…

Biliary Tract Carcinoma altered in cohorts of …ALTERED_INderived15 of 140show all (up to 200)
← altered in cohorts of	HTR6 42 / 51 cases (82 %) · ssm · TCGA-CHOL	—	—	Cholangiocarcinoma	1	Observed	gdc	graph →
← altered in cohorts of	KLHDC7A 42 / 51 cases (82 %) · ssm · TCGA-CHOL	—	—	Cholangiocarcinoma	1	Observed	gdc	graph →
← altered in cohorts of	MRTO4 42 / 51 cases (82 %) · ssm · TCGA-CHOL	—	—	Cholangiocarcinoma	1	Observed	gdc	graph →
← altered in cohorts of	TAS1R2 42 / 51 cases (82 %) · ssm · TCGA-CHOL	—	—	Cholangiocarcinoma	1	Observed	gdc	graph →
← altered in cohorts of	TMCO4 42 / 51 cases (82 %) · ssm · TCGA-CHOL	—	—	Cholangiocarcinoma	1	Observed	gdc	graph →
← altered in cohorts of	AADACL3 41 / 51 cases (80 %) · ssm · TCGA-CHOL	—	—	Cholangiocarcinoma	1	Observed	gdc	graph →
← altered in cohorts of	AADACL4 41 / 51 cases (80 %) · ssm · TCGA-CHOL	—	—	Cholangiocarcinoma	1	Observed	gdc	graph →
← altered in cohorts of	ACTL8 41 / 51 cases (80 %) · ssm · TCGA-CHOL	—	—	Cholangiocarcinoma	1	Observed	gdc	graph →
← altered in cohorts of	AHDC1 41 / 51 cases (80 %) · ssm · TCGA-CHOL	—	—	Cholangiocarcinoma	1	Observed	gdc	graph →
← altered in cohorts of	AKR7A3 41 / 51 cases (80 %) · ssm · TCGA-CHOL	—	—	Cholangiocarcinoma	1	Observed	gdc	graph →
← altered in cohorts of	ALDH4A1 41 / 51 cases (80 %) · ssm · TCGA-CHOL	—	—	Cholangiocarcinoma	1	Observed	gdc	graph →
← altered in cohorts of	ALPL 41 / 51 cases (80 %) · ssm · TCGA-CHOL	—	—	Cholangiocarcinoma	1	Observed	gdc	graph →
← altered in cohorts of	ARHGEF10L 41 / 51 cases (80 %) · ssm · TCGA-CHOL	—	—	Cholangiocarcinoma	1	Observed	gdc	graph →
← altered in cohorts of	ASAP3 41 / 51 cases (80 %) · ssm · TCGA-CHOL	—	—	Cholangiocarcinoma	1	Observed	gdc	graph →
← altered in cohorts of	ATP13A2 41 / 51 cases (80 %) · ssm · TCGA-CHOL	—	—	Cholangiocarcinoma	1	Observed	gdc	graph →

Biliary Tract Carcinoma altered in cohorts of …ALTERED_INderived15 of 140show all (up to 200)

← altered in cohorts of

HTR6

42 / 51 cases (82 %) · ssm · TCGA-CHOL

—

Cholangiocarcinoma

Observed

Biliary Tract Carcinoma investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 106show all (up to 200)
→ investigated in trials for	Gemcitabinesmall molecule 78 trials (29 active) · roll-up of the cancer and its descendants	—	—	Biliary Tract Carcinoma	78	Observed	clinicaltrials	graph →
→ investigated in trials for	Cisplatinsmall molecule 59 trials (25 active) · roll-up of the cancer and its descendants	—	—	Biliary Tract Carcinoma	59	Observed	clinicaltrials	graph →
→ investigated in trials for	Capecitabinesmall molecule 29 trials (11 active) · roll-up of the cancer and its descendants	—	—	Biliary Tract Carcinoma	29	Observed	clinicaltrials	graph →
→ investigated in trials for	Durvalumabmonoclonal antibody 28 trials (21 active) · roll-up of the cancer and its descendants	—	—	Biliary Tract Carcinoma	28	Observed	clinicaltrials	graph →
→ investigated in trials for	Oxaliplatinsmall molecule 26 trials (8 active) · roll-up of the cancer and its descendants	—	—	Biliary Tract Carcinoma	26	Observed	clinicaltrials	graph →
→ investigated in trials for	Pembrolizumabmonoclonal_antibody 23 trials (7 active) · roll-up of the cancer and its descendants	—	—	Biliary Tract Carcinoma	23	Observed	clinicaltrials	graph →
→ investigated in trials for	Fluorouracilsmall molecule 19 trials (7 active) · roll-up of the cancer and its descendants	—	—	Biliary Tract Carcinoma	19	Observed	clinicaltrials	graph →
→ investigated in trials for	Lenvatinibsmall molecule 18 trials (10 active) · roll-up of the cancer and its descendants	—	—	Biliary Tract Carcinoma	18	Observed	clinicaltrials	graph →
→ investigated in trials for	Nab-paclitaxel 12 trials (4 active) · roll-up of the cancer and its descendants	—	—	Biliary Tract Carcinoma	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 11 trials (3 active) · roll-up of the cancer and its descendants	—	—	Biliary Tract Carcinoma	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Leucovorinsmall molecule 11 trials (4 active) · roll-up of the cancer and its descendants	—	—	Biliary Tract Carcinoma	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Pemigatinibsmall molecule 10 trials (3 active) · roll-up of the cancer and its descendants	—	—	Biliary Tract Carcinoma	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Tislelizumabmonoclonal antibody 10 trials (8 active) · roll-up of the cancer and its descendants	—	—	Biliary Tract Carcinoma	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Adebrelimabmonoclonal antibody 8 trials (7 active) · roll-up of the cancer and its descendants	—	—	Biliary Tract Carcinoma	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Irinotecansmall molecule 8 trials (2 active) · roll-up of the cancer and its descendants	—	—	Biliary Tract Carcinoma	8	Observed	clinicaltrials	graph →

Biliary Tract Carcinoma studied in …STUDIED_INderived10 of 823show all (up to 200)
→ studied in	NCT04175912Phase 2 · active not recruiting Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the Liver · condition mapped CURATED_BROADER · 823 trials mapped (300 active)	—	—	Cholangiocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07715903Phase 1 · not yet recruiting Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump Therapy · condition mapped ONTOLOGY_EXACT · 823 trials mapped (300 active)	—	—	Intrahepatic Cholangiocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07766187Phase 2 · not yet recruiting Combination Therapy Using Durvalumab and Histotripsy for Treatment of Intrahepatic Cholangiocarcinoma · condition mapped ONTOLOGY_EXACT · 823 trials mapped (300 active)	—	—	Intrahepatic Cholangiocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07846267Phase 2 · not yet recruiting Cryoablation Combined With Anlotinib Plus TQB2868 in Patients With Advanced Intrahepatic Cholangiocarcinoma · condition mapped ONTOLOGY_EXACT · 823 trials mapped (300 active)	—	—	Intrahepatic Cholangiocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07847710Phase 2 · recruiting Perioperative Retlirafusp Alfa(Anti-PD-L1/TGF-β Bifunctional Fusion Protein) Plus Famitinib and GEMOX-Based Hepatic Arterial Infusion Chemotherapy for Locally Advanced Intrahepatic Cholangiocarcinoma: A Multicenter, Single-Arm, Exploratory Phase II Trial · condition mapped ONTOLOGY_EXACT · 823 trials mapped (300 active)	—	—	Intrahepatic Cholangiocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04645160Phase 1/Phase 2 · recruiting Evaluating Efficacy of Tivozanib (AV-951) in Biliary Tract Cancers · condition mapped ONTOLOGY_EXACT · 823 trials mapped (300 active)	—	—	Cholangiocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05007106Phase 2 · completed MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005) · condition mapped ONTOLOGY_EXACT · 823 trials mapped (300 active)	—	—	Cholangiocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05712356Phase 2 · completed A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients With Advanced Solid Tumors · condition mapped ONTOLOGY_EXACT · 823 trials mapped (300 active)	—	—	Cholangiocarcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07277413Phase 1 · recruiting A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors · condition mapped ONTOLOGY_EXACT · 823 trials mapped (300 active)	—	—	Biliary Tract Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06910670NA · active not recruiting Implementing a Randomized Control Trial to Test the Expanded Web-based Decision Aid · condition mapped ONTOLOGY_EXACT · 823 trials mapped (300 active)	—	—	Cholangiocarcinoma	1	Observed	clinicaltrials	graph →

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