AL Amyloidosis

hematologic malignancy

Identifier: CI-CAN-00008703
Entity page: /cancer/al-amyloidosis ↗
Edges: 109

Neighbours: 23 drugs10 trials
Drawn: 33 of 33 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
AL Amyloidosis investigated for …INVESTIGATED_FOR9 of 9
← investigated for	Melphalansmall_molecule	unknown	3	AL Amyloidosis	1	Curated	chembl	graph →
← investigated for	Dexamethasonesmall_molecule	unknown	3

AL Amyloidosis investigated in trials for …INVESTIGATED_IN_TRIALSderived21 of 21show fewer
→ investigated in trials for	Dexamethasonesmall_molecule 15 trials (8 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	15	Observed	clinicaltrials	graph →
→ investigated in trials for	Daratumumabmonoclonal antibody 9 trials (6 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Teclistamabmonoclonal antibody 6 trials (6 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Pomalidomidesmall_molecule 5 trials (4 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Venetoclaxsmall molecule 5 trials (3 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Bortezomibsmall_molecule 4 trials (3 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall_molecule 4 trials (2 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Ixazomibsmall molecule 4 trials (3 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Belantamab Mafodotinadc 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Bendamustinesmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Elranatamabmonoclonal antibody 2 trials (2 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Isatuximabmonoclonal antibody 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Melphalansmall_molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Ciltacabtagene Autoleucelgene therapy 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Filgrastimother 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Idecabtagene Vicleucelgene therapy 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Lenalidomidesmall_molecule 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Melphalan Flufenamidesmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Selinexorsmall molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Talquetamabmonoclonal antibody 1 trials (1 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Thalidomidesmall_molecule 1 trials (0 active) · roll-up of the cancer and its descendants	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →

AL Amyloidosis investigated in trials for …INVESTIGATED_IN_TRIALSderived21 of 21show fewer

→ investigated in trials for

Dexamethasonesmall_molecule

15 trials (8 active) · roll-up of the cancer and its descendants

—

AL Amyloidosis studied in …STUDIED_INderived10 of 79show all (up to 200)
→ studied in	NCT06768489Phase 1 · recruiting A Study of JNJ-79635322 in Combination With Daratumumab With or Without Lenalidomide for Multiple Myeloma, Newly Diagnosed AL Amyloidosis, and High-risk Smoldering Multiple Myeloma or JNJ-79635322 in Combination With Pomalidomide for Multiple Myeloma · condition mapped ALIAS · 79 trials mapped (43 active)	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT07172243recruiting BE.Amycon Biobank & Data Registry UZ Leuven · condition mapped ONTOLOGY_EXACT · 79 trials mapped (43 active)	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT07215494NA · recruiting A Clinical Study on Minimal Residual Disease in Patients With Systemic Light Chain Amyloidosis · condition mapped ALIAS · 79 trials mapped (43 active)	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT07103863enrolling by invitation Multimodal Radiomics Model (18F-FAPI PET/CT + CMR) for AL Cardiac Amyloidosis Prognosis · condition mapped ONTOLOGY_EXACT · 79 trials mapped (43 active)	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT07615270early Phase 1 · not yet recruiting A Pilot Study of Anselamimab in Patients With AL Amyloidoma and Measurable Tissue Involvement · condition mapped ONTOLOGY_EXACT · 79 trials mapped (43 active)	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT05145816Phase 1/Phase 2 · recruiting Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL Amyloidosis · condition mapped ONTOLOGY_EXACT · 79 trials mapped (43 active)	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT06569147Phase 1/Phase 2 · recruiting Elranatamab in Patients With Relapsed or Refractory AL Amyloidosis · condition mapped ONTOLOGY_EXACT · 79 trials mapped (43 active)	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT07751471Phase 2 · not yet recruiting BCMA/GPRC5D Trispecific Antibody Treatment for Newly Diagnosed Amyloidosis (AL-004) · condition mapped ONTOLOGY_EXACT · 79 trials mapped (43 active)	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT05184088Phase 3 · completed Efficacy of [18F]Florbetaben PET for Diagnosis of Cardiac AL Amyloidosis · condition mapped ONTOLOGY_EXACT · 79 trials mapped (43 active)	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →
→ studied in	NCT07638683Phase 2 · recruiting A Phase II Study to Evaluate the Efficacy and Safety of Teclistamab in Combination With Daratumumab (Tec-Dara) in Newly Diagnosed Multiple Myeloma With Concurrent Light Chain Amyloidosis (MM+AL). · condition mapped ONTOLOGY_EXACT · 79 trials mapped (43 active)	—	—	AL Amyloidosis	1	Observed	clinicaltrials	graph →

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