Acute Megakaryoblastic Leukemia

hematologic malignancy

Identifier: CI-CAN-00001673
Entity page: /cancer/acute-megakaryoblastic-leukemia ↗
Edges: 130

Neighbours: 21 drugs10 trials
Drawn: 31 of 31 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Acute Megakaryoblastic Leukemia investigated for …INVESTIGATED_FOR13 of 13
← investigated for	Thioguaninesmall_molecule	unknown	3	Acute Megakaryoblastic Leukemia	1	Curated	chembl	graph →
← investigated for	Methotrexatesmall_molecule	unknown	3

Acute Megakaryoblastic Leukemia investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 40show all (up to 200)
→ investigated in trials for	Cytarabinesmall_molecule 29 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Megakaryoblastic Leukemia	29	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall_molecule 13 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Megakaryoblastic Leukemia	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Mitoxantronesmall molecule 10 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Megakaryoblastic Leukemia	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Tipifarnibsmall molecule 9 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Megakaryoblastic Leukemia	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Idarubicinsmall_molecule 8 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Megakaryoblastic Leukemia	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Busulfansmall_molecule 7 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Megakaryoblastic Leukemia	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall molecule 7 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Megakaryoblastic Leukemia	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Azacitidinesmall molecule 6 trials (2 active) · roll-up of the cancer and its descendants	—	—	Acute Megakaryoblastic Leukemia	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Daunorubicinsmall_molecule 6 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Megakaryoblastic Leukemia	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Alvocidibsmall molecule 5 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Megakaryoblastic Leukemia	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Bortezomibsmall molecule 5 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Megakaryoblastic Leukemia	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall_molecule 5 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Megakaryoblastic Leukemia	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Vorinostatsmall molecule 5 trials (1 active) · roll-up of the cancer and its descendants	—	—	Acute Megakaryoblastic Leukemia	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Aldesleukinother 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Megakaryoblastic Leukemia	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Decitabinesmall molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Acute Megakaryoblastic Leukemia	3	Observed	clinicaltrials	graph →

Acute Megakaryoblastic Leukemia investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 40show all (up to 200)

→ investigated in trials for

Cytarabinesmall_molecule

29 trials (0 active) · roll-up of the cancer and its descendants

—

Acute Megakaryoblastic Leukemia

Observed

Acute Megakaryoblastic Leukemia studied in …STUDIED_INderived10 of 77show all (up to 200)
→ studied in	NCT00392353Phase 1/Phase 2 · active not recruiting Vorinostat and Azacitidine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia · condition mapped ONTOLOGY_EXACT · 77 trials mapped (2 active)	—	—	Acute Megakaryoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT02071901Phase 2 · completed Eltrombopag Olamine in Improving Platelet Recovery in Older Patients With Acute Myeloid Leukemia Undergoing Chemotherapy · condition mapped ONTOLOGY_EXACT · 77 trials mapped (2 active)	—	—	Adult Acute Megakaryoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT00093470Phase 3 · completed Tipifarnib in Treating Patients With Acute Myeloid Leukemia in Remission · condition mapped ONTOLOGY_EXACT · 77 trials mapped (2 active)	—	—	Adult Acute Megakaryoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT00658814Phase 2 · active not recruiting Azacitidine and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia · condition mapped ONTOLOGY_EXACT · 77 trials mapped (2 active)	—	—	Adult Acute Megakaryoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT01822015early Phase 1 · completed Sirolimus, Idarubicin, and Cytarabine in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia · condition mapped ONTOLOGY_EXACT · 77 trials mapped (2 active)	—	—	Adult Acute Megakaryoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT00588991Phase 1 · completed Veliparib and Topotecan With or Without Carboplatin in Treating Patients With Relapsed or Refractory Acute Leukemia, High-Risk Myelodysplasia, or Aggressive Myeloproliferative Disorders · condition mapped ONTOLOGY_EXACT · 77 trials mapped (2 active)	—	—	Adult Acute Megakaryoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT04083170Phase 2 · terminated Cord Blood Transplant With Dilanubicel for the Treatment of HIV Positive Hematologic Cancers · condition mapped ONTOLOGY_EXACT · 77 trials mapped (2 active)	—	—	Acute Megakaryoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT02085408Phase 3 · completed Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia · condition mapped ONTOLOGY_EXACT · 77 trials mapped (2 active)	—	—	Adult Acute Megakaryoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT01823198Phase 1/Phase 2 · completed Donor Natural Killer Cells and Donor Stem Cell Transplant in Treating Patients With High Risk Myeloid Malignancies · condition mapped ONTOLOGY_EXACT · 77 trials mapped (2 active)	—	—	Acute Megakaryoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT01555268Phase 1 · completed Trebananib With or Without Low-Dose Cytarabine in Treating Patients With Acute Myeloid Leukemia · condition mapped ONTOLOGY_EXACT · 77 trials mapped (2 active)	—	—	Adult Acute Megakaryoblastic Leukemia	1	Observed	clinicaltrials	graph →

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