ZNF703

zinc finger protein 703

Explore in graph →CI-GENE-00039998HGNC:25883 ENSG00000183779 NCBI 80139 CIViC Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FGFR1 Amplification + ZNF703 AmplificationFGFR1 ZNF7031
Letrozole + RibociclibCombination	Malignant Breast Neoplasm	Predictive	B	Supports Resistance	3	submitted	EID12531 In a cohort of 427 patients from the MONALEESA-2 study, which compared aramotase inhibitor letrozole plus CDK4/6 inhibitor ribociclib vs. letrozole plus placebo in patients with ER+/HER2− advanced bre… (full text at CIViC) PMID 30914635 · Formisano et al., 2019 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Urothelial Carcinoma (BCAN/HCRN, Nat Commun 2022) blca_bcan_hcrn_2022	Bladder Urothelial Carcinoma	Ssm	10

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.