XRCC2

X-ray repair cross complementing 2

Explore in graph →CI-GENE-00039005HGNC:12829 ENSG00000196584 NCBI 7516 CIViC Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
XRCC2 Deletion1
Platinum Compound	Gastrointestinal CarcinomaUNRESOLVED	Predictive	C	Supports Sensitivity Response	2	rejected	EID13254 A patient with a gastrointestinal malignancy lacking BRCA1/2 alterations had a homozygous XRCC2 deletion, accompanied by loss of two of three XRCC3 copies, high HRD score (35), high SBS3 exposure (0.0… (full text at CIViC) PMID 36964191 · Tsang et al., 2023 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (9)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved9 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Endometrial and Ovarian Cancer (MSK, Nature Medicine 2024) ucec_msk_2024	unmapped	Ssm	3	33	9.1%

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.