Gene

VSTM2A

V-set and transmembrane domain containing 2A

Explore in graph →CI-GENE-00038630HGNC:28499 ENSG00000170419 NCBI 222008 Approved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
VSTM2A Fusion3
(oncogenic)	IDH-wildtype GlioblastomaUNRESOLVED	Oncogenic	C	Supports Oncogenicity	1	submitted	EID11102 170 cases of IDH-wildtype GBM were screened using whole genome SNP arrays for chromothipsis. 66 cases of 170 demonstrated chromothripsis, of which 52 had adequate RNA available for RNA sequencing. RNA… (full text at CIViC) PMID 33074125 · Ah-Pine et al., 2021 · Open in CIViC	civic
〃	Lung Adenocarcinoma	Oncogenic	E	Supports Oncogenicity	1	submitted	EID11103 Using NGS, genomic profiling from tumor/plasma biopsies from 17,442 Chinese lung cancer patients was performed. EGFR::VSTM2A reported in 2/1053 recurrent kinase fusions in lung cancer (NSCLC, adenocar… (full text at CIViC) PMID 34508169 · Li et al., 2021 ·

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Acute Leukemias of Ambiguous Lineage (TARGET GDC, 2025) alal_target_gdc	Acute Leukemia of Ambiguous Lineage	Ssm	5	123	4.1%

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.