TP53BP1

tumor protein p53 binding protein 1

Explore in graph →CI-GENE-00035915HGNC:11999 ENSG00000067369 NCBI 7158 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TP53BP1 D353E1
(predisposing)	Malignant Lung Neoplasm	Predisposing	E	N/A N/A	2	submitted	EID8046 UK Caucasians were enrolled in a large-scale GWAS study looking for loci associated with lung cancer susceptibility (1529 cases and 2707 controls). Of 64 nonsynonymous, single nucleotide polymorphisms… (full text at CIViC) PMID 16741161 · Rudd et al., 2006 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (78)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved78 cohort rows (showing 28, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
MSK-IMPACT 50K Clinical Sequencing Cohort (MSK, Cancer Cell 2026) msk_impact_50k_2026	unmapped	Ssm	988

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.