Gene

TBK1

TANK binding kinase 1

Explore in graph →CI-GENE-00034690HGNC:11584 ENSG00000183735 NCBI 29110 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TBK1 Overexpression1
AZ909 + SelumetinibCombination	Melanoma	Predictive	D	Supports Sensitivity Response	2	accepted	EID1138 Preclinical study in melanoma cell lines. TBK1 depletion (siRNA) inhibited migration and invasion, whereas its constitutive overexpression led to an increase in invasion. In MEK-resistant NRAS mutant … (full text at CIViC) PMID 24962318 · Vu et al., 2014 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (3)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved3 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Intrahepatic Cholangiocarcinoma (Mount Sinai 2015) ihch_ismms_2015	Intrahepatic Cholangiocarcinoma	Ssm	1

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Targeting TBK1 inhibits migration and resistance to MEK inhibitors in mutant NRAS melanoma.
· Mol Cancer Res · 2014 · PMID 24962318 · validated civic_curation pubmed