Gene

SOX10

SRY-box transcription factor 10

Explore in graph →CI-GENE-00033356HGNC:11190 ENSG00000100146 NCBI 6663 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
SOX10 Loss1
Vemurafenib	Melanoma	Predictive	D	Supports Resistance	4	accepted	EID1710 FACS-assisted shRNA genetic screen identified SOX10 as a determinant of vemurafenib resistance. Suppression of SOX10 in melanoma cells confers resistance to BRAF and MEK inhibitors through activation … (full text at CIViC) PMID 24670642 · Sun et al., 2014 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Pilocytic Astrocytoma (ICGC, Nature Genetics 2013) past_dkfz_heidelberg_2013	Pilocytic Astrocytoma	Ssm	1	96

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma.
· Nature · 2014 · PMID 24670642 · validated civic_curation pubmed