Gene

SIN3A

SIN3 transcription regulator family member A

Explore in graph →CI-GENE-00030675HGNC:19353 ENSG00000169375 NCBI 25942 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
SIN3A mutation2
(oncogenic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11984 The authors analyzed 304 primary DLBCLs using whole exome sequencing and targeted sequencing. This one one of the genes they identified as significantly enriched for somatic mutations. PMID 29713087 · Chapuy et al., 2018 · Open in CIViC	civic
〃	Burkitt Lymphoma	Oncogenic	E	Supports Oncogenicity	3	submitted	EID11829 Described in multiple genome-wide studies of BL PMID 30617194 · Grande et al., 2019 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (7)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved7 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Pre-cancer Colorectal Polyps (HTAN Vanderbilt, Cell 2021) crc_hta11_htan_2021	Colorectal Adenocarcinoma	Ssm	9

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.