Gene

SH2B3

SH2B adaptor protein 3

Explore in graph →CI-GENE-00030517HGNC:29605 ENSG00000111252 NCBI 10019 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
SH2B3 RS31845041
(predisposing)	Malignant Colorectal NeoplasmCURATED_BROADER	Predisposing	B	Supports Predisposition	2	accepted	EID1744 A genome wide association study (GWAS) meta-analysis of 13,265 cancer cases (colorectal cancer and endometrial cancer) and 40,245 controls found this variant to be associated with colorectal cancer (O… (full text at CIViC) PMID 26621817 · Cheng et al., 2015 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (52)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved52 cohort rows (showing 2, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Cancer Therapy and Clonal Hematopoiesis (MSK, Blood Adv 2023) msk_ch_2023	unmapped	Ssm	84	40,521

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.
· Sci Rep · 2015 · PMID 26621817 · validated civic_curation pubmed