Gene

SCAPER

S-phase cyclin A associated protein in the ER

Explore in graph →CI-GENE-00029905HGNC:13081 ENSG00000140386 NCBI 49855 Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
SCAPER Fusion1
(oncogenic)	Pigmented Epithelioid Melanocytoma	Oncogenic	C	Supports Oncogenicity	1	accepted	EID11526 A 4 year old African American girl was seen for a lesion on the scalp. Punch biopsy was done on a largely skin-colored subcutaneous nodule. Subcutaneous nodular aggregations of heavily pigmented epith… (full text at CIViC) PMID 31437301 · Friedman et al., 2020 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (5)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved5 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Metastatic Triple Negative Breast Cancer (UNC Phase II Trial, J Immunother Cancer 2022) - iAtlas Harmonized brca_iatlas_anders_2022	Invasive Breast Carcinoma	Ssm

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

A pediatric case of pigmented epithelioid melanocytoma with chromosomal copy number alterations in 15q and 17q and a novel NTRK3-SCAPER gene fusion.
· J Cutan Pathol · 2020 · PMID 31437301 · validated civic_curation pubmed