RRAS2 Q72L

CI-VAR-00003583Explore in graph →CIViC 3433

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
RRAS2 Q72L	(functional)	Functional	D	Supports Gain Of Function	2	submitted	EID9528 Functional effects of the RRAS2 (TC21) Q72L mutation was assessed in NIH3T3 and 293T cells. RRAS2 Q72L expressed in NIH3T3 cells caused strong activation of AKT by Western blot, higher even than the a… (full text at CIViC) PMID 11850823 · Rong et al., 2002 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.