Gene

RASA1

RAS p21 protein activator 1

Explore in graph →CI-GENE-00022986HGNC:9871 ENSG00000145715 NCBI 5921 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
RASA1 Loss-of-function1
Trametinib	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	D	Supports Sensitivity Response	3	accepted	EID5994 Approximately 2% of NSCLCs had RASA1 truncating mutations, and this alteration was statistically, but not completely, mutually exclusive with known activating EGFR (p=0.02) and KRAS (p=0.02) mutations… (full text at CIViC) PMID 29127119 · Hayashi et al., 2018 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (93)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved93 cohort rows (showing 43, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Non-Small Cell Lung Cancer Brain Metastasis (MSK, Nat Commun 2023) bm_nsclc_mskcc_2023	Lung Non-Small Cell Carcinoma	Ssm

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

RASA1 and NF1 are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non-Small Cell Lung Carcinomas Sensitive to MEK Inhibition.
· Clin Cancer Res · 2018 · PMID 29127119 · validated civic_curation pubmed