PAPPA2

pappalysin 2

Explore in graph →CI-GENE-00018877HGNC:14615 ENSG00000116183 NCBI 60676 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PAPPA2 Y1520X1
Pembrolizumab	Lung Adenocarcinoma	Predictive	C	Supports Sensitivity Response	—	submitted	EID4774 In a retrospective study of 34 non-small cell lung cancer patients, a lung adenocarcinoma patient with PAPPA2 Y1520* nonsense mutation, treated with pembrolizumab monotherapy, was associated with a 4 … (full text at CIViC) PMID 25765070 · Rizvi et al., 2015 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (103)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved103 cohort rows (showing 3, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Chronic Lymphocytic Leukemia (Broad, Nature 2015) cll_broad_2015	Small Lymphocytic Lymphoma	Ssm

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.