NSD2

nuclear receptor binding SET domain protein 2

Explore in graph →CI-GENE-00017283HGNC:12766 ENSG00000109685 NCBI 7468 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NSD2 Mutation1
(oncogenic)	Mantle Cell Lymphoma	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11898 Through a meta-analysis of exome and whole genome sequencing data, this study identified 18 genes that were significantly enriched for mutations in MCL including WHSC1 (NSD2). PMID 32160292 · Pararajalingam et al., 2020 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (64)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved64 cohort rows (showing 14, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Sarcoma (MSK, J Pathol 2023) sarcoma_msk_2023	unmapped	Ssm	1	76	1.3%

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.