Gene

NOTCH2

notch receptor 2

Explore in graph →CI-GENE-00017007HGNC:7882 ENSG00000134250 NCBI 4853 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NOTCH2 Mutation2
(oncogenic)	Mantle Cell Lymphoma	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11902 Through a meta-analysis of exome and whole genome sequencing data, this study identified 18 genes that were significantly enriched for mutations in MCL including NOTCH2. PMID 32160292 · Pararajalingam et al., 2020 · Open in CIViC	civic
〃	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11971 This gene was identified as recurrently mutated in an analysis of 574 DLBCL exomes PMID 29641966 · Schmitz et al., 2018 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (183)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved183 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Lung Adenocarcinoma (MSK, 2021) luad_mskimpact_2021	Lung Adenocarcinoma	Ssm	5	186	2.7%	26

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.