NOTCH2 NM_024408.4(NOTCH2):c.6056G>A (p.Arg2019Gln)

CI-VAR-00031767Explore in graph →p.Arg2019GlnNM_024408.4:c.6056G>AClinVar 196923 rs201446896

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
196923	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	Hajdu-Cheney syndrome; Alagille syndrome due to a NOTCH2 point mutation; Papillary renal cell carcinoma type 1; Clear cell carcinoma of kidney	germline	4	Jun 18, 2025	clinvar