NECTIN4

nectin cell adhesion molecule 4

Explore in graph →CI-GENE-00016556HGNC:19688 ENSG00000143217 NCBI 81607 CIViC Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NECTIN4 D594H1
Enfortumab Vedotin	Malignant NeoplasmALIAS	Predictive	D	Supports Sensitivity Response	3	submitted	EID7656 Enfortumab Vedotin (also known as AGC-22ME or AGS-22M6E), but not unconjugated AGS-22M6 or control ADC, induced dose-dependent inhibition of cell viability both in T-47D cells and in PC-3 cells transf… (full text at CIViC) PMID 27013195 · Challita-Eid et al., 2016 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (4)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved4 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Skin Cutaneous Melanoma(Broad, Cancer Discov 2014) skcm_broad_brafresist_2012	Cutaneous Melanoma	Ssm	17	78

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.