Gene

NCOA1

nuclear receptor coactivator 1

Explore in graph →CI-GENE-00016364HGNC:7668 ENSG00000084676 NCBI 8648 Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NCOA1 Fusion1
(diagnostic)	Supratentorial Ependymoma ZFTA Fusion-Positive	Diagnostic	C	Supports Positive	2	accepted	EID11428 In an analysis of 13 cases of supratentorial glial tumors with ZFTA rearrangements without RELA involvement, all were found to have DNA methylation profiles similar to ZFTA::RELA supratentorial ependy… (full text at CIViC) PMID 34389065 · Tauziède-Espariat et al., 2021 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (11)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved11 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Squamous Cell Carcinoma of the Vulva (CUK, Exp Mol Med 2018) vsc_cuk_2018	Vaginal Squamous Cell Carcinoma, Not Otherwise Specified	Ssm

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions.
· Acta Neuropathol Commun · 2021 · PMID 34389065 · validated civic_curation pubmed