Gene

MS4A1

membrane spanning 4-domains A1

Explore in graph →CI-GENE-00015125HGNC:7315 ENSG00000156738 NCBI 931 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MS4A1 Mutation1
R-CHOP Regimen	Diffuse Large B-Cell LymphomaCURATED_BROADER	Predictive	B	Supports Resistance	3	accepted	EID10367 A targeted sequencing study of 135 relapsed/refractory DLBCL patients identified an association between missense mutations in MS4A1 and acquired resistance to R-CHOP. PMID 32589730 · Rushton et al., 2020 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (1)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved1 cohort row · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Adenoid Cystic Carcinoma (Sanger/MDA, JCI 2013) acyc_sanger_2013	Adenoid Cystic Carcinoma	Ssm	1	24

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Genetic and evolutionary patterns of treatment resistance in relapsed B-cell lymphoma.
· Blood Adv · 2020 · PMID 32589730 · validated civic_curation pubmed