MPL

MPL proto-oncogene, thrombopoietin receptor

Explore in graph →CI-GENE-00014832HGNC:7217 ENSG00000117400 NCBI 4352 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (6)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–6 of 6 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MPL Mutation2
(diagnostic)	Essential Thrombocythemia	Diagnostic	A	Supports Positive	5	submitted	EID6383 Diagnostic criterion for essential thrombocytemia according to the World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues 2016.

Cohorts

Alteration frequency by cohort (53)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved53 cohort rows (showing 3, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Cancer Therapy and Clonal Hematopoiesis (MSK, Blood Adv 2023) msk_ch_2023	unmapped	Ssm	34	42,714

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.

MPL S204P3
(oncogenic)	Myeloproliferative NeoplasmCURATED_BROADER	Oncogenic	B	Supports Oncogenicity	3	submitted	EID11008 Comprehensive genomic characterization was undertaken in a total of 2035 patients including 1321 patients with essential thrombocythemia, 356 with polycythemia vera, 309 with myelofibrosis, and 49 wit… (full text at CIViC) PMID 30304655 · Grinfeld et al., 2018 · Open in CIViC	civic
(functional)	—UNRESOLVED	Functional	C	Supports Gain Of Function	3	submitted	EID11009 Seventeen patients diagnosed as triple-negative ETs namely negative for any JAK2V617F, MPLW515K/L, and CALR exon 9 mutations were studied via WES on paired granulocyte and T-cell samples (considered a… (full text at CIViC) PMID 26450985 · Cabagnols et al., 2016 · Open in CIViC	civic
〃	—UNRESOLVED	Functional	D	Supports Gain Of Function	3	submitted	EID11007 MPL S204P was identified somatically in 2 individuals with PMF and ET. Using a luciferase reporter assay in JAK2- deficient gamma 2A cells, S204P and other identified MPL variants (T119I, S204F, E230… (full text at CIViC) PMID 26423830 · Milosevic Feenstra et al., 2016 · Open in CIViC	civic

MPL W515L1
(oncogenic)	Primary MyelofibrosisALIAS	Oncogenic	D	Supports Oncogenicity	3	submitted	EID7221 Found MPL W515L mutation in 4/45 MF patients' bone marrow but not cheek DNA. Expression of the mutated gene in cell cultures (BaF3, 3D, or UT-7 cells) resulted increased cell growth, and in mice (via … (full text at CIViC) PMID 16834459 · Pikman et al., 2006 · Open in CIViC	civic