MPL S204P

CI-VAR-00004019Explore in graph →CIViC 4290

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Myeloproliferative Neoplasm1
MPL S204P	(oncogenic)	Oncogenic	B	Supports Oncogenicity	3	submitted	EID11008 Comprehensive genomic characterization was undertaken in a total of 2035 patients including 1321 patients with essential thrombocythemia, 356 with polycythemia vera, 309 with myelofibrosis, and 49 wit… (full text at CIViC) PMID 30304655 · Grinfeld et al., 2018 · Open in CIViC	civic
Unmapped disease2unmapped disease
MPL S204P	(functional)	Functional	C	Supports Gain Of Function	3	submitted	EID11009 Seventeen patients diagnosed as triple-negative ETs namely negative for any JAK2V617F, MPLW515K/L, and CALR exon 9 mutations were studied via WES on paired granulocyte and T-cell samples (considered a… (full text at CIViC) PMID 26450985 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.