Gene
MAP2K7
mitogen-activated protein kinase kinase 7
Explore in graph →CI-GENE-00011960HGNC:6847 ENSG00000076984 NCBI 5609 CIViC Cancer geneApproved
Curated evidence
Clinical evidence (4)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 27028764
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| MAP2K7 E116K1 | ||||||||
| (prognostic) | Malignant Lung Neoplasm | Prognostic | B | Supports Poor Outcome | 5 | accepted | EID1420Study examined rare SNPs on MAP2K7 among a discovery and two validation cohorts. It was discovered that the E116K genotype was associated with a reduced median survival time of 4 and 7 months for E/K … (full text at CIViC) PMID 27028764 · Qiu et al., 2016 · Open in CIViC | civic |
| MAP2K7 Loss-of-function3 | ||||||||
| (oncogenic) | Estrogen Receptor-positive Breast CancerUNRESOLVED | Oncogenic | D | Supports Oncogenicity | 4 | submitted | EID13221MAP2K7 loss promoted metastatic behavior in an ER-positive breast cancer model. CRISPR/Cas9 MAP2K7-knockout MCF-7 cells showed >97% suppression of MKK7 protein and were compared with vector-control ce… | |
Cohorts
Alteration frequency by cohort (1)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 28667006
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Cholangiocarcinoma (ICGC, Cancer Discov 2017) chol_icgc_2017 | Cholangiocarcinoma | Ssm | 8 | 417 |
Literature
Linked publications (1)
25 per page, newest first.
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
· PLoS Genet · 2016 · PMID 27028764 · validated civic_curation pubmed