Gene

LZTR1

leucine zipper like post translational regulator 1

Explore in graph →CI-GENE-00011773HGNC:6742 ENSG00000099949 NCBI 8216 CIViC Approved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
LZTR1 G248R1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	2	submitted	EID9317 Missense mutations in the Kelch domains of LTZR1 were tested for their RAS-binding ability. A co-immunoprecipitation assay showed that G248R caused reduced binding with RAS, suggesting a loss of RAS u… (full text at CIViC) PMID 30442762 · Steklov et al., 2018 · Open in CIViC	civic
LZTR1 LOSS-OF-FUNCTION1
(predisposing)	Schwannomatosis	Predisposing	B	Supports Pathogenic	5	submitted	EID7058 Germline loss-of-function mutations in LZTR1 is a SMARCB1-independent predisposing factor that leads to Schwannomatosis, a late-onset tumor predisposition disorder. PMID 24362817 ·

Cohorts

Alteration frequency by cohort (25)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved25 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Endometrial Carcinoma (MSK, Molecular Oncology 2024) ucs_msk_2024	Endometrial Carcinoma	Ssm	5	25

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.