KDM5A

lysine demethylase 5A

Explore in graph →CI-GENE-00006806HGNC:9886 ENSG00000073614 NCBI 5927 Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
KDM5A Fusion1
(prognostic)	Acute Megakaryoblastic LeukemiaALIAS	Prognostic	B	Supports Poor Outcome	4	submitted	EID8502 Acute megakaryoblastic leukemia (AMKL) is a rare subtype of AML. CBFA2T3/GLIS2 and NUP98/KDM5A are recurrent aberrations, occurring in similar frequencies as RBM15/MKL1 and KMT2A-rearrangements. In th… (full text at CIViC) PMID 27114462 · de Rooij et al., 2016 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (127)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved127 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023) egc_msk_2023	unmapped	Ssm	25	902

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.