Gene

IL6

interleukin 6

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
IL6 Overexpression2
Bazedoxifene	Rhabdomyosarcoma	Predictive	D	Supports Resistance	2	accepted	EID7956 Treatment with bazedoxifene inhibited cell colony formation in rhabdomyosarcoma cell lines RH30 and RD. Addition of excess IL6 reduced the inhibitory effect of bazedoxifene on colony formation. PMID 28672024 · Xiao et al., 2017 · Open in CIViC	civic
Cisplatin	Esophageal Carcinoma	Predictive	D	Supports Resistance	3	submitted	EID7851 Two human esophageal squamous cell carcinoma cell lines, KYSE170 and TE13, were transfected with the IL6 gene. These cell lines produced 5-6 fold (KYSE170) and 16-17 fold (TE13) IL6 compared to contr… (full text at CIViC) PMID 21273582 · Suchi et al., 2011 · Open in CIViC	civic

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

Data not yet available

No cohort frequency recorded for this gene.

Literature

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.