IL6 Overexpression

CI-VAR-00003198Explore in graph →CIViC 2911

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Esophageal Carcinoma1
IL6 Overexpression	Cisplatin	Predictive	D	Supports Resistance	3	submitted	EID7851 Two human esophageal squamous cell carcinoma cell lines, KYSE170 and TE13, were transfected with the IL6 gene. These cell lines produced 5-6 fold (KYSE170) and 16-17 fold (TE13) IL6 compared to contr… (full text at CIViC) PMID 21273582 · Suchi et al., 2011 · Open in CIViC	civic
Rhabdomyosarcoma1
IL6 Overexpression	Bazedoxifene	Predictive	D	Supports Resistance	2	accepted	EID7956 Treatment with bazedoxifene inhibited cell colony formation in rhabdomyosarcoma cell lines RH30 and RD. Addition of excess IL6 reduced the inhibitory effect of bazedoxifene on colony formation. PMID 28672024 · Xiao et al., 2017 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.