Gene

IGF1R

insulin like growth factor 1 receptor

Explore in graph →CI-GENE-00005488HGNC:5465 ENSG00000140443 NCBI 3480 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (4)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
IGF1R EXPRESSION1
Gefitinib	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	D	Supports Resistance	2

Cohorts

Alteration frequency by cohort (119)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved119 cohort rows (showing 19, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Prostate Adenocarcinoma (MSK, Cancer Cell 2010) prad_mskcc	Prostate Adenocarcinoma	Ssm	1

Literature

Linked publications (3)

25 per page, newest first.

pubmedPublishedShowing 1–3 of 3 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

The influence of insulin-like Growth Factor-1-Receptor expression and endocrine treatment on clinical outcome of postmenopausal hormone receptor positive breast cancer patients: A Dutch TEAM substudy analysis.
· Mol Oncol · 2016 · PMID 26706833 · validated civic_curation pubmed
Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas.
· Eur J Cancer · 2012 · PMID 22682017 · validated civic_curation pubmed
Insulin-like growth factor-1 receptor (IGF-1R) as a biomarker for resistance to the tyrosine kinase inhibitor gefitinib in non-small cell lung cancer.
· Cell Oncol (Dordr) · 2013 · PMID 23619944 · validated civic_curation pubmed

IGF1R Overexpression2
Exemestane + MetforminCombination	Malignant Breast Neoplasm	Predictive	B	Supports Sensitivity Response	4	accepted	EID10138 A randomized phase III trial of hormone sensitive (ER or PR positive) early stage breast cancer (Dutch TEAM cohort, n=2,446) examined the addition of metformin to exemestane for 155 patients. IGF1R IH… (full text at CIViC) PMID 26706833 · Engels et al., 2016 · Open in CIViC	civic
Crizotinib + Gefitinib + LinsitinibCombination	Salivary Gland Adenoid Cystic Carcinoma	Predictive	D	Supports Sensitivity Response	3	submitted	EID9024 Within a preclinical study 15 patient samples with adenoid cystic carcinoma MYB-NFIB fusion activation loop can be modulated through AKT-dependent signaling induced by IGF1R overexpression and downreg… (full text at CIViC) PMID 28954282 · Andersson et al., 2017 · Open in CIViC	civic