HDAC6 Overexpression

CI-VAR-00003221Explore in graph →CIViC 3599

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Esophageal Neoplasm1
HDAC6 Overexpression	Panobinostat + Trichostatin A + Vorinostat	Predictive	D	Supports Sensitivity Response	2	submitted	EID9856 HDAC expression was assessed from 27 esophageal squamous cell carcinoma (ESCC) cell lines to determine the efficacy of HDAC inhibitors and found that practically all 10 HDAC (HDAC1, HDAC2, HDAC3, HDAC… (full text at CIViC) PMID 30484863 · Cheng et al., 2018 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.