Gene

HAVCR2

hepatitis A virus cellular receptor 2

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
HAVCR2 Overexpression2
PD1 Inhibitor	Lung Adenocarcinoma	Predictive	C	Supports Resistance	3	accepted	EID1150 In a preclinical study in an immunocompetent mouse model of lung adenocarcinoma, upregulation of alternative immune checkpoints, notably T-cell immunoglobulin mucin-3 (TIM-3, aka HAVCR2) was observed … (full text at CIViC) PMID 26883990 · Koyama et al., 2016 · Open in CIViC	civic
Anti-TIM-3 Monoclonal Antibody + PD1 InhibitorCombination	Lung Adenocarcinoma	Predictive	D	Supports Sensitivity Response	3	accepted	EID1151 In a preclinical study in an immunocompetent mouse model of lung adenocarcinoma, upregulation of alternative immune checkpoints, notably T-cell immunoglobulin mucin-3 (TIM-3, aka HAVCR2) was observed … (full text at CIViC) PMID ·

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

Data not yet available

No cohort frequency recorded for this gene.

Literature

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.