Gene

FOXO3

forkhead box O3

Explore in graph →CI-GENE-00002183HGNC:3821 ENSG00000118689 NCBI 2309 CIViC Approved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FOXO3 Mutation2
(prognostic)	Choroid Plexus Carcinoma	Prognostic	A	Supports Poor Outcome	3	rejected	EID7223 From UniProt: A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. PMID 26822237 · Parsons et al., 2016 · Open in CIViC	civic
(functional)	Choroid Plexus Carcinoma	Functional	D	Supports Loss Of Function	4	rejected	EID7222 Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. PMID 26822237 · Parsons et al., 2016 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (4)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved4 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Thymic Epithelial Tumors (NCI, Nat Genet 2014) tet_nci_2014	Thymus Epithelial Neoplasm	Ssm	1	32

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.