FOXO3 Mutation

CI-VAR-00002702Explore in graph →CIViC 2668

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Choroid Plexus Carcinoma2
FOXO3 Mutation	(prognostic)	Prognostic	A	Supports Poor Outcome	3	rejected	EID7223 From UniProt: A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. PMID 26822237 · Parsons et al., 2016 · Open in CIViC	civic
FOXO3 Mutation	(functional)	Functional	D	Supports Loss Of Function	4	rejected	EID7222 Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. PMID 26822237 · Parsons et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.