FOXA1 Mutation

CI-VAR-00002847Explore in graph →CIViC 5436

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Estrogen Receptor-positive Breast Cancer1unmapped disease
FOXA1 Mutation	Aromatase Inhibitor	Predictive	B	Supports Resistance	2	submitted	EID12910 In a retrospective cohort of metastatic ER+ breast cancer treated with single‑agent aromatase inhibitors (n = 304; FOXA1‑mut n = 17; FOXA1‑WT n = 287). Somatic FOXA1 missense mutations were associated… (full text at CIViC) PMID 32888433 · Arruabarrena-Aristorena et al., 2020 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.