Gene

FLCN

folliculin

Explore in graph →CI-GENE-00002025HGNC:27310 ENSG00000154803 NCBI 201163 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FLCN c.1285dupC1
Everolimus	Renal Cell CarcinomaCURATED_BROADER	Predictive	C	Supports Sensitivity Response	1	accepted	EID10137 A case study showed that the mTOR inhibitor everolimus exhibited a relatively long-term effect in a patient with renal cell carcinoma and a FLCN germline mutation (c. 1285dupC, likely loss of function… (full text at CIViC) PMID 23995526 · Nakamura et al., 2013 · Open in CIViC	civic
FLCN Loss1
Sirolimus	Kidney CarcinomaALIAS	Predictive	D	Supports Sensitivity Response	3	submitted	EID5991 Genetic disruption of Flcn in mouse kidney distal tubule cells leads to tumorigenic transformation of these cells to develop allograft tumors with an aggressive histologic phenotype. mTOR pathway play…

Cohorts

Alteration frequency by cohort (62)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved62 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Osteosarcoma TARGET-OS	Osteosarcoma	Ssm

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

[A case of metastatic renal cell carcinoma associated with Birt-Hogg-Dubé syndrome treated with molecular-targeting agents].
· Hinyokika Kiyo · 2013 · PMID 23995526 · validated civic_curation pubmed

FLCN Mutation1
Everolimus	Papillary Renal Cell Carcinoma	Predictive	C	Supports Sensitivity Response	3	submitted	EID5990 In a patient with Birt-Hogg-Dubé syndrome-associated papillary renal cell carcinoma use of everolimus as sixth-line systematic treatment exhibited a relatively long-term effect as compared with the pr… (full text at CIViC) PMID 23995526 · Nakamura et al., 2013 · Open in CIViC	civic

FLCN Mutation1

Everolimus

Papillary Renal Cell Carcinoma

Predictive

Supports Sensitivity Response

submitted

EID5990

In a patient with Birt-Hogg-Dubé syndrome-associated papillary renal cell carcinoma use of everolimus as sixth-line systematic treatment exhibited a relatively long-term effect as compared with the pr… (full text at CIViC)

PMID 23995526 · Nakamura et al., 2013 · Open in CIViC

civic