Gene

ETV1

ETS variant transcription factor 1

Explore in graph →CI-GENE-00001066HGNC:3490 ENSG00000006468 NCBI 2115 CIViC Approved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ETV1 Overexpression2
Trametinib	Malignant Pancreatic Neoplasm	Predictive	D	Supports Resistance	3	submitted	EID5117 In vitro studies in KRAS G12V pancreatic cancer cells (PATU8902) showed that overexpression of ETV1 reduced sensitivity to trametinib. PMID 28178529 · Wang et al., 2017 · Open in CIViC	civic
〃	Malignant Lung Neoplasm	Predictive	D	Supports Resistance	3	submitted	EID5118 In vitro studies in KRAS G12C lung cancer cells (CALU1) showed that overexpression of ETV1 modulated resistance to trametinib. PMID 28178529 · Wang et al., 2017 · Open in CIViC	civic
ETV1 Fusion

Cohorts

Alteration frequency by cohort (64)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved64 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Prostate Cancer (MSK, Cell Metab 2020) prad_msk_2019	unmapped	Ssm	2	18	11.1%

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.